A phosphate tether-mediated, one-pot, sequential ring-closing metathesis/cross-metathesis/chemoselective hydrogenation protocol.

Organic Letters
Phanindra K M VenukadasulaPaul R Hanson

Abstract

A versatile three-step, one-pot, sequential reaction protocol involving ring-closing metathesis, cross-metathesis, and chemoselective hydrogenation is reported. This phosphate tether-mediated process occurs without intermediate isolation, is chemoselective, and is governed by stereoelectronic properties innate to phosphate tethers, which ultimately act to preserve the integrity of the bisallylic, bicyclic phosphate for subsequent nucleophilic additions. Overall, this process can be used to efficiently generate advanced polyol synthons.

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Citations

Jan 14, 2016·Organic Letters·Mahipal BodugamPaul R Hanson
Oct 10, 2014·Beilstein Journal of Organic Chemistry·Paul R HansonRambabu Chegondi
Sep 25, 2018·The Journal of Organic Chemistry·Denis N Prada GoriCarina M L Delpiccolo

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