A phospholipase A2-related snake venom (from Crotalus durissus terrificus) stimulates neuroendocrine and immune functions: determination of different sites of action

Endocrinology
A ChisariR C Gaillard

Abstract

Immune neuroendocrine interactions are vital for the individual's survival in certain physiopathological conditions, such as sepsis and tissular injury. It is known that several animal venoms, such as those from different snakes, are potent neurotoxic compounds and that their main component is a specific phospholipase A type 2 (PLA2). It has been described recently that the venom from Crotalus durissus terrificus [snake venom (SV), in the present study] possesses some cytotoxic effect in different in vitro and in vivo animal models. In the present study, we investigated whether SV and its main component, PLA2 (obtained from the same source), are able to stimulate both immune and neuroendocrine functions in mice, thus characterizing this type of neurotoxic shock. For this purpose, several in vivo and in vitro designs were used to further determine the sites of action of SV-PLA2 on the hypothalamo-pituitary-adrenal (HPA) axis function and on the release of the pathognomonic cytokine, tumor necrosis factor alpha (TNF alpha), of different types of inflammatory stress. Our results indicate that SV (25 microg/animal) and PLA2 (5 microg/animal), from the same origin, stimulate the HPA and immune axes when administered (i.p.) to adult ...Continue Reading

References

Nov 16, 1992·Biochemical and Biophysical Research Communications·L G ElliesJ E Aubin
Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R M BurchJ Axelrod
Jan 1, 1986·Annual Review of Biochemistry·P NeedlemanJ B Lefkowith
Mar 1, 1987·Biochemical Pharmacology·C F BennettS T Crooke
Aug 1, 1987·Biochemical Pharmacology·J ChangH McGregor
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K RübsamenE Habermann
Dec 1, 1971·The American Journal of Physiology·L A Frohman, L L Bernardis
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G D SnyderJ R Falck
Feb 10, 1984·European Journal of Pharmacology·P L CanonicoR M MacLeod
Mar 30, 1984·Journal of Immunological Methods·D A Flick, G E Gifford
Jun 30, 1982·Neuroscience Letters·J V Halliwell, J O Dolly
Feb 1, 1993·Investigational New Drugs·R E CorinM A Etcheverry

❮ Previous
Next ❯

Citations

Jul 20, 2004·Clinical Microbiology Reviews·Ian A ClarkWilliam B Cowden
Sep 25, 2008·Nature Clinical Practice. Nephrology·Visith Sitprija
Jul 30, 1999·The American Journal of Clinical Nutrition·S S Yeh, M W Schuster
Jul 27, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Polianna Lemos Moura Moreira AlbuquerqueElizabeth De Francesco Daher
Jan 30, 2010·Toxicon : Official Journal of the International Society on Toxinology·Sandra C SampaioYara Cury

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.