A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell

Bioconjugate Chemistry
Takeshi TohgasakiMasayuki Endo

Abstract

We report a nanosized DNA capsule with a photoinducible mechanical unlocking system for creation of a carrier for delivery system to the cells. A photocage system was introduced into the nanocapsule (NC) for control of opening of the NC with photoirradiation. The opening of the NC was observed by atomic force microscopy (AFM), and the dynamic opening of the NC was examined by fluorescence recovery from the quenching. The photocaged NC was introduced to the cell without toxicity and observed in the cytoplasm, and the photoinduced opening of the NC was observed in the cell. The selective unlocking and opening of the caged-NC in a single cell was successfully achieved by a laser irradiation to individual cells.

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Citations

Aug 23, 2020·Micromachines·Kan Shoji, Ryuji Kawano
Dec 2, 2020·Emerging Topics in Life Sciences·Ioanna Mela, Clemens F Kaminski
May 14, 2021·Trends in Biotechnology·Jiahui Zhang, Khalid Salaita
May 14, 2021·Chemical Communications : Chem Comm·Katsuhiko AbeMasayuki Endo

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