A photoimmobilizable sulfobetaine-based polymer for a nonbiofouling surface

Materials Science & Engineering. C, Materials for Biological Applications
Makoto SakuragiYoshihiro Ito

Abstract

A novel photoreactive polymer containing sulfobetaine polar groups was prepared by copolymerization of two kinds of methacrylic acids with sulfobetaine and azidoaniline. The polymer was photoimmobilized on polyester and polystyrene surfaces. Its effects on surface modification were investigated from its interactions with water, proteins and cells. Polymer immobilization altered both of the plain surfaces to becoming hydrophilic in a similar range of static contact angles (12.5±1.6° on polyester and 14.7±2.2° on polystyrene). This suggests that the surfaces were covered with sulfobetaine polar groups. Micropattern immobilization was carried out on both polymers using a photomask. The formed pattern was identical to the photomask, showing that the polymer was formed in response to ultraviolet irradiation. Measurements using atomic force microscopy showed that the polymer was formed at a thickness of 550nm, demonstrating that the polymer was cross-linked with itself and with the substrate molecules. Measurements using time-of-flight secondary ion mass spectrometry detected an abundance of sulfur-containing ions in the patterned polymer, confirming that sulfobetaine had been immobilized. Protein adsorption and mammalian cell adhesi...Continue Reading

Citations

Jan 27, 2017·Biomaterials Science·Hsiu-Wen ChienWei-Bor Tsai
Aug 15, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Vivek Arjunan VasanthaAnbanandam Parthiban
May 25, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Dušana Trel'ováIgor Lacík

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