A physical approach to remove anatomical reentries: a bidomain study

Journal of Theoretical Biology
S TakagiValentin Krinsky

Abstract

Controlling cardiac chaos is often achieved by applying a large damaging electric shock-defibrillation. It removes all waves, without differentiating reentries and normal waves, anatomical and functional reentries. Anatomical reentries can be removed by anti-tachycardia pacing (ATP) as well. But ATP requires the knowledge of the position of the reentry, and an access to it with an invasive stimulating electrode. We show that the physics of electric field distribution between cardiac cells permits one to deliver an electric pulse exactly to the core of an anatomical reentry, without knowing its position and even to locations where access with a stimulating electrode is not possible. The energy needed is two orders of magnitude less than defibrillation energy. The results are insensitive to both a detailed ionic model and to the geometry of the fibers.

References

Jun 1, 1977·The Journal of Physiology·G W Beeler, H Reuter
Apr 1, 1986·IEEE Transactions on Bio-medical Engineering·B J Roth, J P Wikswo
Sep 12, 1996·The American Journal of Cardiology·M Rosenqvist
Aug 6, 1999·Journal of Theoretical Biology·A Pumir, V Krinsky
Jun 5, 2003·Chaos·Sitabhra SinhaDavid J. Christini
Jun 5, 2003·Chaos·Natalia TrayanovaFelipe Aguel
Oct 29, 1951·The Journal of Physiology·S WEIDMANN
Mar 6, 2004·IEEE Transactions on Bio-medical Engineering·Niels F Otani

❮ Previous
Next ❯

Citations

Jun 5, 2003·Chaos·V. Krinsky, A. Pumir
Apr 7, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Philip BittihnStefan Luther
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marcel HörningKenichi Yoshikawa
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marcel HörningKenichi Yoshikawa
Jul 16, 2017·Physical Review. E·Kei NishiYasumasa Nishiura
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marcel HörningKenichi Yoshikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.