PMID: 2497062Apr 1, 1989Paper

A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line

Genomics
J RagoussisA Ziegler

Abstract

To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2 haplotype. Results were obtained mainly by field-inversion gel electrophoresis and Southern blotting techniques. The map extends to 4800 kb and includes the HLA complex with a length of 4200 kb. Five HTF islands could be positioned on the map. The class I region has a size of about 2000 kb and includes nonclassical HLA class I genes, some of which must be localized within 200 kb telomeric of HLA-A. A new class I gene, cda12, distinct from HLA-A, HLA-B, or HLA-C, has been localized within 50 kb from HLA-A. The class I region contains a gap of about 500 kb, just telomeric of HLA-C, in which further class I genes could not be detected. The class II region has a size of 1000 kb, which is separated from the class I region by about 1200 kb. The 5' end of the HLA-B gene is situated centromeric, giving an orientation opposite to that of the TNFA and TNFB loci. The estimated length of the HLA complex correlates well with its size determined cytogenetically using mutant cell lines with i...Continue Reading

References

Jan 1, 1988·British Journal of Rheumatology·E H WeissG Riethmüller
Sep 1, 1987·Journal of Clinical Pathology·W F Bodmer
Nov 11, 1987·Nucleic Acids Research·H Inoko, J Trowsdale
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H A ErlichD Pious
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P GladstoneD Pious

❮ Previous
Next ❯

Citations

Aug 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C M Milner, R D Campbell
Jan 1, 1990·Immunologic Research·H Heinrichs, H T Orr
May 23, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T LappT Reinhard
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Jul 1, 1993·Immunology Today·R D Campbell, J Trowsdale
Jul 1, 1991·Human Immunology·C M Schmidt, H T Orr
May 1, 1992·Human Immunology·J G BodmerT Sasazuki
Sep 1, 1994·Human Immunology·A CorellA Arnaiz-Villena
Oct 1, 1989·Current Opinion in Immunology·D M Altmann, J Trowsdale
Sep 9, 1999·Journal of Reproductive Immunology·A Arnaiz-VillenaJ Martinez-Laso
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J RagoussisJ Trowsdale
Aug 11, 1991·Nucleic Acids Research·H ShuklaS M Weissman
Jan 1, 1992·Vox Sanguinis·J G BodmerT Sasazuki
Jun 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J G BodmerT Sasazuki
Feb 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G MartinelliS Tura
Jan 1, 1993·Immunobiology·J G BodmerT Sasazuki
Dec 1, 1991·Immunology Today·J TrowsdaleR D Campbell
Dec 1, 1992·Genomics·C P Venditti, M J Chorney
Feb 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J Trowsdale, R D Campbell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.