PMID: 3762307Oct 6, 1986Paper

A physico-chemical comparison of aortic receptors in rat hypertension models

Life Sciences
W J MeyerH H Nguyen

Abstract

Rat models of genetic hypertension include spontaneous hypertension and resistance or sensitivity to mineralocorticoid and salt induced hypertension. Previously, altered aldosterone binding to corticoid receptor I was found in aortic smooth muscle cells cultured from Fischer 344 rats which are extremely resistant to steroid and salt induced hypertension. The corticoid receptor I of Fisher 344 rats had a lower affinity than that of salt sensitive Wistar-Kyoto controls, as well as spontaneously hypertensive rats and Sprague-Dawley rats. In the present study, we have used DEAE-cellulose ion exchange chromatography to compare the structure (charge properties) and steroid specificity of vascular corticoid receptor I and II sites in these same rat hypertension models. No variations in ion exchange properties of type I and II receptors were found. Together with the lower aldosterone affinity of corticoid receptor I sites in Fischer 344 rats these data suggest an altered binding domain which is not seen as a difference in charge density of the receptor protein by ion exchange chromatography.

References

Jan 1, 1979·Physiological Reviews·J Chamley-CampbellR Ross
May 1, 1985·Journal of Steroid Biochemistry·N R NicholsW J Meyer
Dec 1, 1983·Journal of Hypertension·N R NicholsW J Meyer
Nov 1, 1981·Journal of Steroid Biochemistry·W J Meyer, N R Nichols
Feb 1, 1982·Journal of Steroid Biochemistry·L KornelW J Raynor
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J E Griffin, J L Durrant

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Citations

Jun 14, 2003·Fundamental & Clinical Pharmacology·Laetitia HerinJean-Luc Elghozi
Dec 29, 2005·Hypertension·Anthony R WhiteDan E Berkowitz

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