A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice

Gene
Francesco ErricoRoberto Di Lauro

Abstract

Free D-aspartic acid and NMDA are present in the mammalian central nervous system and endocrine glands at significant concentrations, but their physiological role is still matter of debate. The only enzyme known to metabolize in vitro selectively these D-amino acids is D-aspartate oxidase (DDO). To clarify the role in vivo of the enzyme, we generated mice with targeted deletion of Ddo gene by homologous recombination. Mutated animals showed increased amounts of both D-aspartic acid and NMDA in all tissues examined demonstrating a physiological role of DDO in the regulation of their endogenous levels.

References

Aug 25, 1992·Biochimica Et Biophysica Acta·M SasakiJ Enami
Jan 23, 1991·Biochimica Et Biophysica Acta·P P Van VeldhovenG P Mannaerts
Nov 26, 1986·Biochemical and Biophysical Research Communications·D S DunlopA Lajtha
Feb 1, 1983·Genetics·R Konno, Y Yasumura
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G E Fagg, A Matus
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Mar 1, 1995·Biomedical Chromatography : BMC·K ImaiT Santa
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Apr 1, 1997·Journal of Biochemistry·C Setoyama, R Miura
Jul 31, 1998·Neuroscience Letters·S IshioY Moriyama
Aug 11, 1998·Nature Genetics·M De FeliceR Di Lauro
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A D'AnielloD Ingrosso

❮ Previous
Next ❯

Citations

Oct 27, 2010·Amino Acids·Atsushi YamamotoKihachiro Horiike
Apr 27, 2011·Amino Acids·Mendel Friedman, Carol E Levin
Aug 2, 2012·Amino Acids·Francesco ErricoAlessandro Usiello
Aug 16, 2012·Amino Acids·Masahiro YamanakaRyuichi Konno
Jun 6, 2012·Parkinson's Disease·Veronica GhiglieriPaolo Calabresi
Jan 1, 2009·Reviews in the Neurosciences·Francesco ErricoAlessandro Usiello
Jul 16, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hiroko OhideRyuichi Konno
Apr 29, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Masumi Katane, Hiroshi Homma
Nov 6, 2007·Molecular and Cellular Neurosciences·Francesco ErricoAlessandro Usiello
Aug 29, 2012·British Journal of Pharmacology·G GrasselliD Centonze
Jun 22, 2010·Chemistry & Biodiversity·Masumi Katane, Hiroshi Homma
Apr 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Francesco ErricoAlessandro Usiello
Mar 17, 2015·Neurobiology of Aging·Luigia CristinoAlessandro Usiello
May 17, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea de BartolomeisFelice Iasevoli
Jul 10, 2013·Journal of Psychiatric Research·Francesco ErricoAlessandro Usiello
Dec 15, 2015·Biology of Reproduction·Keiji TomitaAkihiro Kawauchi
Nov 6, 2018·The FEBS Journal·Yasuaki SaitohHiroshi Homma
Sep 6, 2019·Biomolecules·Maria Maddalena Di FioreGabriella Chieffi Baccari
Feb 12, 2020·Applied Microbiology and Biotechnology·Shouji Takahashi
Jul 7, 2017·Amino Acids·Giuseppe Genchi
Jan 6, 2017·Scientifica·Yoshimitsu Kiriyama, Hiromi Nochi
Aug 28, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Tommaso NuzzoAlessandro Usiello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Alex S HuangSolomon H Snyder
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Francesco ErricoAlessandro Usiello
Proceedings of the National Academy of Sciences of the United States of America
M J SchellS H Snyder
© 2021 Meta ULC. All rights reserved