A physiological role for gene loops in yeast.

Genes & Development
Jean-Philippe LainéMichael Hampsey

Abstract

DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes have been identified in yeast and mammalian cells. Loop formation is transcription-dependent and requires components of the pre-mRNA 3'-end processing machinery. Here we report that looping at the yeast GAL10 gene persists following a cycle of transcriptional activation and repression. Moreover, GAL10 and a GAL1p-SEN1 reporter undergo rapid reactivation kinetics following a cycle of activation and repression-a phenomenon defined as "transcriptional memory"-and this effect correlates with the persistence of looping. We propose that gene loops facilitate transcriptional memory in yeast.

References

Dec 9, 1998·Cell·F C HolstegeR A Young
Jun 14, 2001·Methods : a Companion to Methods in Enzymology·O PuigB Séraphin
Feb 16, 2002·Science·Job DekkerNancy Kleckner
May 29, 2003·Molecular Cell·Gene O Bryant, Mark Ptashne
Aug 18, 2004·Nature Genetics·Justin M O'SullivanNick J Proudfoot
Sep 30, 2004·PLoS Biology·Jason H Brickner, Peter Walter
Dec 2, 2005·Genes & Development·Athar Ansari, Michael Hampsey
Apr 18, 2007·Genes & Development·Sharmistha KunduCraig L Peterson
Sep 7, 2007·Molecular Cell·Badri Nath Singh, Michael Hampsey
Nov 13, 2007·Current Biology : CB·Ioannis ZacharioudakisDimitris Tzamarias
Jan 8, 2008·Current Biology : CB·Mark Ptashne
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sue Mei Tan-WongMelissa A Brown
Feb 3, 2009·Current Opinion in Cell Biology·Jason H Brickner
Mar 10, 2009·Methods : a Companion to Methods in Enzymology·Badri Nath SinghMichael Hampsey
Jul 16, 2009·The Journal of Biological Chemistry·Belal El KaderiAthar Ansari

❮ Previous
Next ❯

Citations

Nov 19, 2011·Chromosoma·Chunhui Hou, Victor G Corces
May 15, 2013·Trends in Genetics : TIG·Daniel Hebenstreit
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
Oct 24, 2012·Nature Reviews. Molecular Cell Biology·Marcela Raices, Maximiliano A D'Angelo
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aboudi M MoabbiAthar Ansari
Sep 17, 2011·The Journal of Biological Chemistry·Banupriya Mukundan, Athar Ansari
Aug 19, 2011·The Journal of Biological Chemistry·Bo O Zhou, Jin-Qiu Zhou
Jun 9, 2012·The Journal of Biological Chemistry·Sara C CloutierElizabeth J Tran
Feb 11, 2012·Molecular Biology of the Cell·Erin M GreenKarsten Weis
Jan 5, 2012·Genes & Development·Elzo de Wit, Wouter de Laat
Aug 3, 2012·Genes & Development·Terence R Strick, Nouria Hernandez
May 19, 2011·Development, Growth & Differentiation·Michelle StevenseTetsuya Muramoto
Nov 3, 2012·Science·Michael Hampsey
Mar 10, 2010·Molecular and Cellular Biology·Sharmistha Kundu, Craig L Peterson
Jan 20, 2011·PLoS Biology·Jamie M KramerAnnette Schenck
Sep 12, 2012·Genetics·Angela Taddei, Susan M Gasser
Apr 24, 2014·Nature Reviews. Molecular Cell Biology·Philipp A Steffen, Leonie Ringrose
Oct 15, 2013·Molecular Biology and Evolution·Zhiming DaiXianhua Dai
May 15, 2012·Annual Review of Biophysics·Einat GrossmanMonika Zwerger
Nov 7, 2012·Biochimica Et Biophysica Acta·Giorgio DieciRoberto Ferrari
Jul 11, 2014·Molecular Biology of the Cell·David Mayhew, Robi D Mitra
Oct 25, 2014·Nucleic Acids Research·Ralph S GrandJustin M O'Sullivan
Mar 12, 2013·The Journal of Biological Chemistry·Banupriya Mukundan, Athar Ansari
Mar 9, 2011·The Journal of Cell Biology·Christophe Zimmer, Emmanuelle Fabre
Sep 3, 2014·Journal of Molecular Biology·Danling ZhuCaroline Dean
May 24, 2011·Trends in Genetics : TIG·Wu WeiLars M Steinmetz
Jan 19, 2011·Current Opinion in Cell Biology·Ghislaine Arib, Asifa Akhtar
Nov 3, 2010·Advances in Enzyme Regulation·Michael HampseyShankarling Krishnamurthy
Jul 6, 2010·Current Opinion in Genetics & Development·Wulan Deng, Gerd A Blobel
Jan 12, 2010·Biochimica Et Biophysica Acta·Judith A Jaehning
Feb 10, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·David W Van de VosseJohn D Aitchison
May 9, 2014·The Plant Journal : for Cell and Molecular Biology·Laetitia VirlouvetMichael Fromm
Feb 1, 2014·Current Opinion in Genetics & Development·Varun Sood, Jason H Brickner
Aug 22, 2015·Genome Biology·Chang Liu, Detlef Weigel
Mar 25, 2014·Current Opinion in Cell Biology·Christopher PtakRichard W Wozniak
Jan 18, 2012·Biochimica Et Biophysica Acta·Alexander F Palazzo, Abdalla Akef
Jan 14, 2012·Biochimica Et Biophysica Acta·Anna BabourFrançoise Stutz
Feb 19, 2015·Nucleic Acids Research·Christelle MorelleLaurence Lachaud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.