A physiologically active interpenetrating collagen network that supports growth and migration of epidermal keratinocytes: zinc-polyP nanoparticles integrated into compressed collagen.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Werner E G MüllerXiaohong Wang

Abstract

The distinguished property of the physiological polymer, inorganic polyphosphate (polyP), is to act as a bio-intelligent material which releases stimulus-dependent metabolic energy to accelerate wound healing. This characteristic is based on the bio-imitating feature of polyP to be converted, upon exposure to peptide-containing body fluids, from stable amorphous nanoparticles to a physiologically active and energy-delivering coacervate phase. This property of polyP has been utilized to fabricate a wound mat consisting of compressed collagen supplemented with amorphous polyP particles, formed from the inorganic polyanion with an over-stoichiometric ratio of zinc ions. The proliferation and the migration of human skin keratinocytes in those matrices were investigated. If the cells were embedded into the mat they respond with a significantly higher motility when zinc-polyP particles are present. Interestingly, only keratinocytes that were grown in a polyP environment developed well-structured microvilli, reflecting an increased biological activity. The data show that Zn-polyP particles incorporated into wound mats are a potent cell growth and cell migration-stimulating inorganic bio-material.

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Citations

Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shunfeng WangWerner E G Müller
Aug 15, 2021·International Journal of Biological Macromolecules·Minghao ZhangFei Hang

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Methods Mentioned

BETA
X-ray
scanning electron microscopy

Software Mentioned

MatTek

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