A physiologically active polysaccharide hydrogel promotes wound healing

Journal of Biomedical Materials Research. Part a
Yi LuoJunfeng Zhang

Abstract

When the skin is injured, the subcutaneous tissues and organs are threatened by pathogens and excessive water loss. Wound dressings are, therefore, needed to protect the wound site from infection and improve the wound closure. Natural polysaccharides have been applied for various biomaterials including wound dressings, which show their advantages in biocompatibility, low toxicity, and pharmaceutical biomedical activity. In this study, a natural polysaccharide Bletilla striata polysaccharide (BSP) hydrogel is prepared by an oxidation and crosslinking methods. This BSP hydrogel represents preferable swelling ability and appropriate water vapor transmission rate. Using a full-thickness trauma mouse model, the hydrogel is applied on the in vivo cutaneous wound healing. Compared with the control groups, the BSP hydrogel achieves the much better healing results. The quantification of the infiltrating inflammatory cells and the level of tumor necrosis factor alpha (TNF-alpha) in the BSP group are attenuated, whereas the secretion of the epidermal growth factor (EGF) is highly elevated. On the 11th day after surgery, the wound area in the BSP hydrogel group is only 1/5-1/3 of those in the control groups. This new BSP hydrogel is proved...Continue Reading

References

Dec 1, 1972·Analytical Biochemistry·R F Itzhaki
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·S K Purna, M Babu
Feb 22, 2000·JAMA : the Journal of the American Medical Association·Y M Bello, T J Phillips
Nov 15, 2000·Journal of Biomedical Materials Research·K A SmedsM W Grinstaff
Aug 22, 2001·Trends in Cell Biology·V Baud, M Karin
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·S M StrukovaE Glusa
Nov 17, 2001·Biomacromolecules·V NormandP Aymard
Aug 15, 2002·Nitric Oxide : Biology and Chemistry·Ann SchwentkerTimothy R Billiar
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Apr 21, 2004·Annals of Biomedical Engineering·Dana L NettlesLori A Setton
Feb 2, 2006·Journal of Cell Science·Stephen C GilliverGillian S Ashcroft
May 26, 2006·International Wound Journal·Douglas QueenGeoff Sussman
Dec 19, 2006·American Journal of Clinical Dermatology·Véronique VoinchetJérôme Kern
Jan 9, 2007·Biomacromolecules·Wojciech K CzajaR Malcolm Brown
Feb 6, 2007·Clinics in Dermatology·Nathan B MenkeRobert F Diegelmann
Feb 6, 2007·Clinics in Dermatology·Liza G Ovington
Jan 29, 2008·Journal of the American Academy of Dermatology·Margaret A FonderAdam J Mamelak
Apr 15, 2009·Archives of Ophthalmology·C Starck JohnsonTerry Kim

❮ Previous
Next ❯

Citations

Nov 2, 2014·ACS Applied Materials & Interfaces·Mariana Teixeira CerqueiraAlexandra Pinto Marques
Aug 12, 2014·Applied Biochemistry and Biotechnology·Dzianis SmirnouVladimír Velebný
Jul 3, 2013·Pharmacological Reviews·George J ChristKarl-Erik Andersson
Oct 17, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·ShiHua LuoGanSheng Feng
Aug 6, 2016·Pharmaceutical Development and Technology·Xiuming CuiGang Peng
Feb 2, 2019·Journal of Biomedical Materials Research. Part a·Monika PatelKazuaki Matsumura
Sep 11, 2019·International Journal of Molecular Sciences·Fusheng JiangGuiyuan Lv
Nov 14, 2019·Journal of Natural Medicines·Yuto NishidonoKen Tanaka
Jan 1, 2015·Burns and Trauma·Xiaorong ZhangWeifeng He
Apr 8, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chen ZhangYan Qu
May 13, 2017·Chinese Journal of Integrative Medicine·Shi-Hua LuoGan-Sheng Feng
Apr 1, 2016·Journal of Food and Drug Analysis·Hsin-Yi Hung, Tian-Shung Wu
Jun 7, 2019·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Man ZhangLianghong Yin
Apr 18, 2018·Advanced Healthcare Materials·Guoming SunJohn W Harmon
May 6, 2020·Marine Drugs·Tingting YanSidong Li
Aug 11, 2021·ACS Nano·Yongping LiangBaolin Guo
Mar 14, 2018·Chemical Reviews·Farzad SeidiDaniel Crespy
Sep 28, 2021·Journal of Wound Care·Hsin-Chung TsaiChuan-Mu Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.