A physiologically representative in vitro model of the coronary circulation

Physiological Measurement
Maartje C F GevenFrans N van de Vosse

Abstract

With the development of clinical diagnostic techniques to investigate the coronary circulation in conscious humans, the in vitro validation of such newly developed techniques is of major importance. The aim of this study was to develop an in vitro model that is able to mimic the coronary circulation in such a way that coronary pressure and flow signals under baseline as well as hyperaemic conditions are approximated as realistically as possible and are in accordance with recently gained insights into such signals in conscious man. In the present in vitro model the heart, the systemic and coronary circulation are modelled on the basis of the elements of a lumped parameter mathematical model only consisting of elements that can be represented by segments in an experimental set-up. A collapsible tube, collapsed by the ventricular pressure, represents the variable resistance and volume behaviour of the endocardial part of the myocardium. The pressure and flow signals obtained are similar to physiological human coronary pressure and flow, both for baseline and hyperaemic conditions. The model allows for in vitro evaluation of clinical diagnostic techniques.

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Citations

Apr 22, 2008·Annals of Biomedical Engineering·Mahmoud MaasraniAgnes Drochon
Jun 11, 2008·Medical & Biological Engineering & Computing·Nico WesterhofBerend E Westerhof
Apr 15, 2010·Journal of Biomechanical Engineering·E GaillardL-G Durand
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Aug 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marcel van 't VeerBernard De Bruyne
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