A pilot feasibility study of non-cultured autologous skin cell suspension for healing diabetic foot ulcers.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
S Tawqeer RashidFrank L Bowling

Abstract

A prospective, single arm feasibility study was conducted to evaluate healing outcomes of DFUs treated with autologous skin cell suspension (ASCS) in combination with standard therapy. Wounds up to 100 cm2 in size that failed to heal with conventional therapy were included and wound healing, pain, exudate scores, Quality of Life, satisfaction scores, and safety outcomes were evaluated over a period of 26 weeks. Sixteen subjects were enrolled having a mean DFU duration of 60.4 weeks. All ulcers in this study had a positive healing trajectory, with a mean reepithelialization of 84.9% and 12.2 cm2 reduction in ulcer area. For ulcers that did not acquire a soft tissue infection post-treatment, all either healed or achieved ≥95% reepithelialization including some with exposed tendon. Improvements were observed in all aspects of the health-related Quality of Life questionnaire and subjects and clinicians were highly satisfied across all postoperative visits. This preliminary study suggests ASCS is a well-tolerated and promising therapy for the treatment of DFUs as all ulcers evaluated experienced positive healing results regardless of size, depth, and wound duration. Future studies are warranted to investigate ASCS compared to standa...Continue Reading

References

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Mar 19, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Abigail M WojtowiczDolores Baksh
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Dec 16, 2017·International Wound Journal·Julian F GuestPeter Vowden
Jan 30, 2018·Annals of the New York Academy of Sciences·Estelle Everett, Nestoras Mathioudakis

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Citations

Sep 21, 2021·Tissue Engineering. Part C, Methods·Shiva MotamediHassan Niknejad

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