A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia.

NeuroImage
S A MedaGodfrey Pearlson

Abstract

Understanding genetic influences on both healthy and disordered brain function is a major focus in psychiatric neuroimaging. We utilized task-related imaging findings from an fMRI auditory oddball task known to be robustly associated with abnormal activation in schizophrenia, to investigate genomic factors derived from multiple single nucleotide polymorphisms (SNPs) from genes previously shown to be associated with schizophrenia. Our major aim was to investigate the relationship of these genomic factors to normal/abnormal brain functionality between controls and schizophrenia patients. We studied a Caucasian-only sample of 35 healthy controls and 31 schizophrenia patients. All subjects performed an auditory oddball task, which consists of detecting an infrequent sound within a series of frequent sounds. Each subject was characterized on 24 different SNP markers spanning multiple risk genes previously associated with schizophrenia. We used a recently developed technique named parallel independent component analysis (para-ICA) to analyze this multimodal data set (Liu et al., 2008). The method aims to identify simultaneously independent components of each modality (functional imaging, genetics) and the relationships between them. ...Continue Reading

References

Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·C L EhlersR I Chaplin
Jul 1, 1988·Electroencephalography and Clinical Neurophysiology·J Polich, E Donchin
May 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·P McGuffinI I Gottesman
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Oct 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R D Pascual-MarquiD Lehmann
Oct 1, 1995·Biological Psychology·J Polich, A Kok
May 1, 1997·IEEE Transactions on Bio-medical Engineering·S Baillet, L Garnero
Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·E HalgrenP Chauvel
Sep 29, 1999·Neuroreport·T YoshiuraY Numaguchi
Feb 10, 2000·Schizophrenia Bulletin·A G CardnoP McGuffin
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jul 30, 2002·Psychopathology·Michael B First
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·F J BayleM O Krebs
Nov 13, 2003·Genome Biology·Su-In Lee, Serafim Batzoglou
Jan 31, 2004·Nature Genetics·Joachim Hallmayer
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·V E GolimbetE I Rogaev
Jul 10, 2004·Trends in Cognitive Sciences·Terry E Goldberg, Daniel R Weinberger
Sep 24, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seong Hoon JeongYong Sik Kim
Apr 30, 2005·Biological Psychiatry·Kent A KiehlJohn H Krystal
May 12, 2005·Schizophrenia Research·Kristin R LaurensPeter F Liddle
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joseph H CallicottDaniel R Weinberger
Nov 15, 2005·European Archives of Psychiatry and Clinical Neuroscience·G J E SchmittE M Meisenzahl
Dec 2, 2005·Schizophrenia Bulletin·Nick CraddockMichael J Owen
Mar 3, 2007·The American Journal of Psychiatry·Abigail G GarrityVince D Calhoun
Mar 16, 2007·Psychiatry Research·Daniel H WolfJ Daniel Ragland
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Regina HünnerkopfKlaus Peter Lesch
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Nov 3, 2007·The American Journal of Psychiatry·Michael C StevensKent A Kiehl
Nov 24, 2007·Schizophrenia Bulletin·Godfrey D Pearlson, Bradley S Folley
Nov 30, 2007·Human Molecular Genetics·Michael E TalkowskiVishwajit L Nimgaonkar

❮ Previous
Next ❯

Citations

Nov 23, 2011·Molecular Psychiatry·B FrankeUNKNOWN International Multicentre persistent ADHD CollaboraTion
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefano MarencoDaniel R Weinberger
Dec 4, 2013·Journal of the American Statistical Association·Francesco C StingoVince D Calhoun
Mar 19, 2014·Social Psychiatry and Psychiatric Epidemiology·Ceren AkdenizAndreas Meyer-Lindenberg
Jan 10, 2013·Annual Review of Clinical Psychology·Gregory A Miller, Brigitte Rockstroh
Jan 9, 2014·Brain Imaging and Behavior·Paul M ThompsonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Shashwath A MedaGodfrey D Pearlson
Jun 28, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Vince D Calhoun, Jing Sui
Nov 24, 2011·Journal of Neuroscience Methods·Jing SuiVince D Calhoun
Mar 9, 2013·Annals of the New York Academy of Sciences·Hollis C KarolyKent E Hutchison
Oct 15, 2011·Human Brain Mapping·Hannes RugeFrini Karayanidis
Mar 24, 2012·NeuroImage·Jiayu ChenJingyu Liu
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Giulio PergolaGiuseppe Blasi
Nov 5, 2011·NeuroImage·Andreas Meyer-Lindenberg
Apr 12, 2014·Frontiers in Neuroinformatics·Jingyu Liu, Vince D Calhoun
Dec 17, 2016·Brain Imaging and Behavior·Natàlia Vilor-TejedorJuan R González
Jun 22, 2018·Clinical EEG and Neuroscience·Emine Elif TulayMehmet Kemal Arıkan
Aug 3, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angélica Salatino-OliveiraMara H Hutz
Aug 24, 2019·Journal of Molecular Neuroscience : MN·Feng-Ling XuBao-Jie Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.