A pilot prospective study of fetomaternal hemorrhage identified by anemia in asymptomatic neonates

Journal of Perinatology : Official Journal of the California Perinatal Association
Annemarie Stroustrup, Callie Plafkin

Abstract

Fetomaternal hemorrhage (FMH) is a poorly understood condition in which fetal erythrocytes transfer to the maternal circulation via a faulty placental barrier. Little is known about the true incidence, epidemiology or pathophysiology of FMH in the general pregnant population as existing studies are based on retrospective cohorts and manifest diagnosis and selection bias. The objective of this study was to evaluate the practicability of a prospective study of FMH in the general population based on antepartum maternal blood testing and neonatal anemia. Prospective cohort study. Nineteen pregnant women were enrolled prior to the term delivery of 20 well infants. Five neonates were unexpectedly anemic on first postnatal testing. Antenatal maternal blood samples associated with two of the five anemic newborns had positive Kleihauer-Betke testing while no newborn with a normal postnatal blood count had an associated abnormal Kleihauer-Betke test. Clinically significant FMH may be more common than previously thought. Prospective epidemiological study of FMH is feasible.

References

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Citations

Jun 8, 2019·Archives of Pathology & Laboratory Medicine·Matthew S KarafinUNKNOWN College of American Pathologists Transfusion, Apheresis, and Cellular Therapy Committee

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Methods Mentioned

BETA
flow cytometry
Cesarean

Clinical Trials Mentioned

NCT01232387

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Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

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