A pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of labor

Acta Obstetricia Et Gynecologica Scandinavica
H LamP C Ho

Abstract

To compare sublingual misoprostol with intravenous syntometrine use during third stage of labor by measuring the blood loss. Sixty women were randomized to receive either 600 micro g misoprostol sublingually or 1 ml syntometrine intravenously during the third stage of labor after spontaneous vaginal delivery. For those with risk factors of postpartum hemorrhage such as medical induction or augmentation of labor, previous third stage complications were excluded. The blood loss in labor was measured by the alkaline-hematin method, and differences in hemoglobin before and after delivery were compared. There was no significant difference in the median measured blood loss between the misoprostol group and the syntometrine group (280 versus 226 ml, p = 0.45). The change in hemoglobin was comparable between the two groups. There were more women in the misoprostol group who required additional oxytocics, but the difference was not statistically significant. A major complication occurred in one patient in the misoprostol group with blood loss in excess of 1000 ml. The incidence of side effects such as shivering and pyrexia in women receiving misoprostol was significantly higher than that in the syntometrine group. The use of sublingual ...Continue Reading

References

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Citations

Sep 17, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·N EftekhariR Lashkarizadeh
Jan 4, 2017·Taiwanese Journal of Obstetrics & Gynecology·Essam Rashad OthmanMohammed Khairy Ali
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Jul 17, 2013·The Cochrane Database of Systematic Reviews·G Justus HofmeyrTheresa A Lawrie
Jun 8, 2018·The Cochrane Database of Systematic Reviews·Tippawan LiabsuetrakulQ Monir Islam
Jul 25, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gunjan SinghKiran Guleria
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Özge TunçalpA Metin Gülmezoglu
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Apr 22, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·N L SloanB Winikoff
Mar 2, 2019·Health Technology Assessment : HTA·Ioannis GallosArri Coomarasamy
Feb 4, 2006·Clinical Obstetrics and Gynecology·Whitney B You, Christopher M Zahn
Nov 29, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C Langenbach
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Oct 10, 2015·Basic & Clinical Pharmacology & Toxicology·Şenol ŞentürkFigen Kır Şahin
Nov 22, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Picklu ChaudhuriApurba Mandal
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Preeti VermaVanita Suri

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