A pilot randomized-controlled trial of the urodynamic efficacy of mirabegron for patients with neurogenic lower urinary tract dysfunction

Neurourology and Urodynamics
Blayne WelkKaren Ethans

Abstract

To determine the effectiveness of mirabegron in patients with neurogenic lower urinary tract dysfunction. Randomized, double-blind, placebo-controlled study. Canadian patients with spinal cord injury (SCI) or multiple sclerosis (MS) with urinary symptoms and incontinence were recruited. Patients were randomized to mirabegron 25 mg (or an identical placebo) for 2 weeks at which point a dose escalation to mirabegron 50 mg (or an identical placebo) was maintained for 8 weeks. Urodynamics were performed before and after treatment. The primary outcome measure was maximum cystometric capacity (MCC). Intention to treat analysis and ANCOVA models (with adjustment for baseline values) were used and marginal means (MM) are reported; P-value <0.05 was considered significant. Sixteen (9 SCI and 7 MS) patients were randomized to mirabegron and 16 (10 SCI and 6 MS) to placebo. At study completion, there was no significant difference in MCC between mirabegron and placebo (MM 305 vs 369 mL, P = 0.20). There was no significant difference in volume at first neurogenic detrusor overactivity (NDO, MM 167 vs 137 mL, P = 0.14) and peak pressure of NDO (MM 69 vs 82 cmH2 O, P = 0.25). There was no significant difference in pad weights or voiding diary...Continue Reading

References

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Citations

Feb 28, 2020·The Journal of Spinal Cord Medicine·Denise G TateMarcel W Post
Mar 21, 2020·Neurourology and Urodynamics·Blayne WelkUNKNOWN Neurogenic Bladder Research Group
May 14, 2020·Current Opinion in Urology·Pedro Abreu-MendesCarlos Martins-Silva
Dec 6, 2019·World Journal of Urology·Elie El HelouElie Nemr
Jun 4, 2019·Therapeutic Advances in Neurological Disorders·Marilena GubbiottiAntonella Giannantoni
Apr 20, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Pawan VasudevaDiganta Borah
Jan 31, 2020·Continuum : Lifelong Learning in Neurology·Jalesh N Panicker, Ryuji Sakakibara
Aug 11, 2020·Frontiers in Systems Neuroscience·Yuriy SysoevPavel Musienko
Oct 15, 2019·International Neurourology Journal·Argyrios StampasSuzanne L Groah
Apr 25, 2020·World Journal of Urology·John S WienerRaimund Stein
Feb 23, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Noritoshi SekidoToyohiko Watanabe
Oct 17, 2020·Seminars in Neurology·Jalesh N Panicker

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