A Pilot Randomized Controlled Trial to Explore Cognitive and Emotional Effects of Probiotics in Fibromyalgia

Scientific Reports
P RomanDiana Cardona

Abstract

It has recently been found that microbes in the gut may regulate brain processes through the gut microbiota-brain axis, which modulates affection, motivation and higher cognitive functions. According to this finding, the use of probiotics may be a potential treatment to improve physical, psychological and cognitive status in clinical populations with altered microbiota balance such as those with fibromyalgia (FMS). Thus, the aim of the present pilot study with a double-blind, placebo-controlled, randomised design was to test whether a multispecies probiotic may improve cognition, emotional symptoms and functional state in a sample of patients diagnosed with FMS. Pain, impact of FMS, quality of life, anxiety and depressive symptoms were measured during the pre- and post-intervention phases; participants also completed two computerised cognitive tasks to assess impulsive choice and decision-making. Finally, urinary cortisol concentration was determined. To our knowledge, this is the first study that explore the effect of a multispecies probiotic in FMS patients. Our results indicated that probiotics improved impulsivity and decision-making in these patients. However, more research is needed to further explore the potential effect...Continue Reading

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Citations

Sep 5, 2018·Behavioural Pharmacology·Pablo RomanAlda Cortes-Rodríguez
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Dec 8, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cristofer Ruiz-GonzalezDiana Cardona
Apr 4, 2021·International Journal of Environmental Research and Public Health·Diana CardonaNuria Sánchez-Labraca
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Jun 26, 2021·Neuroscience and Biobehavioral Reviews·Jessica EastwoodDaniel Lamport
Jul 24, 2021·British Medical Bulletin·Filippo MiglioriniGiorgia Colarossi

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT02642289

Software Mentioned

ERGYPHILUS
Prime
GraphPad Prism
SPSS

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