A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids

Food & Nutrition Research
Nicole Landa CavallaroGeoffrey A Walford

Abstract

Elevated fasting levels of branched chain amino acids (BCAAs: valine, isoleucine, leucine) in venous blood are associated with a variety of metabolic impairments, including increased risk of type 2 diabetes (T2D). Fasting BCAA levels are influenced by non-dietary factors. However, it is unknown whether fasting BCAAs can be altered through manipulation of dietary intake alone. To test whether a specific dietary intervention, using differences in BCAA intake, alters fasting BCAA levels independent of other factors. Five healthy male volunteers underwent 4 days of a low and 4 days of a high BCAA content dietary intervention (ClinicalTrials.gov [NCT02110602]). All food and supplements were provided. Fasting BCAAs were measured from venous blood samples by mass spectrometry at baseline and after each intervention. Diets were isocaloric; contained equal percentages of calories from carbohydrate, fats, and protein; and differed from each other in BCAA content (1.5±0.1 vs. 14.0±0.6 g for valine; 4.5±0.9 g vs. 13.8±0.5 g for isoleucine; 2.1±0.2 g vs. 27.1±1.0 g for leucine; p<0.0001 for all). Fasting valine was significantly lower (p=0.02) and fasting isoleucine and leucine were numerically lower following the low BCAA content vs. the h...Continue Reading

Associated Clinical Trials

References

Oct 9, 1969·The New England Journal of Medicine·P FeligG F Cahill
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Jul 5, 2013·Cell Metabolism·Eugene P RheeRobert E Gerszten

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Methods Mentioned

BETA
gastric bypass

Clinical Trials Mentioned

NCT02110602

Software Mentioned

Nutrition Data System for Research
MultiQuant
Nutrition Data System for
GraphPad Prism
Pronutra

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