A pilot study examining germline minisatellite mutations in the offspring of Danish childhood and adolescent cancer survivors treated with radiotherapy.

International Journal of Radiation Biology
Gwen S ReesJohn D Boice

Abstract

To investigate germline mutation rate at eight minisatellite loci in 24 Danish families, where one parent is the survivor of childhood or adolescent cancer treated with radiotherapy. Parents and offspring were profiled for eight hypervariable minisatellite loci (B6.7, CEB1, CEB15, CEB25, CEB36, MS1, MS31, MS32) by Southern blotting. Seven paternal mutations were observed for 130 informative alleles in 18 offspring from 11 radiation-exposed fathers (mean preconceptional dose for offspring 0.29 Gy, range<0.01-1.2 Gy), compared to six mutations for 146 informative alleles in 21 offspring from 13 unexposed fathers. No statistically significant difference between the total paternal mutation rates was observed (5.4% for exposed fathers and 4.1% for unexposed fathers). Three maternal mutations were observed for 148 informative alleles in 21 offspring from 13 radiation-exposed mothers (mean preconceptional dose for offspring 0.71 Gy, range <0.01-9.2 Gy), compared to one mutation for 130 informative alleles in 18 offspring from 11 unexposed mothers. Again, no statistically significant difference was observed between the total maternal mutation rates (2.0% for exposed mothers and 0.8% for unexposed mothers). The data from this pilot stud...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E BoerwinkleL Chan
Apr 25, 1996·Nature·Y E DubrovaA J Jeffreys
Jul 19, 2000·Genome Research·G Vergnaud, F Denoeud
Sep 28, 2000·Mutation Research·C A MayM L Meistrich
Jan 15, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·B Lord, J Hendry
Feb 9, 2002·Science·Yuri E DubrovaSisko Salomaa
Jul 11, 2003·Health Physics·John D BoiceMarilyn Stovall
Dec 4, 2003·Mutation Research·Yuri E Dubrova
Apr 7, 2004·Mutation Research·Robbert J C SlebosJack A Taylor
Apr 24, 2004·American Journal of Human Genetics·Jeanette Falck WintherJorgen H Olsen
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Marilyn StovallJohn D Boice
Feb 24, 2005·Mutation Research·Katsumi FuritsuTaisei Nomura

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Citations

Sep 4, 2009·International Journal of Cancer. Journal International Du Cancer·Laura-Maria S Madanat-HarjuojaRisto Sankila
Aug 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Angela B Edgar, W Hamish B Wallace
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jeanette F WintherJørgen H Olsen
Sep 25, 2012·Mutation Research·Sergei V Jargin
Jul 27, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C DufourF De Vathaire
Nov 23, 2010·International Journal of Radiation Biology·E Janet TawnJohn D Boice
Jun 10, 2016·International Journal of Cancer. Journal International Du Cancer·Viivi I SeppänenLaura-Maria Madanat-Harjuoja

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