A pilot study for combination chemotherapy using gemcitabine and S-1 for advanced pancreatic cancer

Oncology
Yousuke NakaiMasao Omata

Abstract

We performed a pilot study of a modified combination chemotherapy regimen with S-1 plus gemcitabine for patients with advanced pancreatic cancer. Gemcitabine was administered at a dose of 1,000 mg/m(2) in a 30-min intravenous injection on days 1 and 15. S-1 was administered orally at a dose of 40 mg/m(2) twice daily for 14 consecutive days followed by a 14-day rest. Each cycle was repeated every 28 days. Sixteen patients were enrolled. No complete response was observed and partial response was observed in 5 patients (31.3%), stable disease in 10 patients (62.5%) and progressive disease in 1 patient (6.3%). The median time to progression was 10.0 months (95% CI 4.4-N.A.) and the median survival time was 20.4 months (95% CI 8.6-24.1 months). The major toxicities were grade 3 neutropenia (25.0%) and grade 3 anemia (6.3%). There were no grade 4 toxicities. Combination therapy with gemcitabine and S-1 using the modified 4-week schedule was well tolerated and efficacious for advanced pancreatic cancer.

Citations

Jun 22, 2010·Cancer Chemotherapy and Pharmacology·Takashi SasakiKazuhiko Koike
May 14, 2010·Japanese Journal of Clinical Oncology·Yousuke NakaiKazuhiko Koike
May 15, 2010·Pancreas·Yousuke NakaiKazuhiko Koike
May 26, 2011·World Journal of Clinical Oncology·Minoru TadaKazuhiko Koike
Apr 29, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shunji NagaiAkimasa Nakao
Jun 29, 2010·Critical Reviews in Oncology/hematology·Yousuke NakaiKazuhiko Koike
Jul 3, 2015·Journal of Hepato-biliary-pancreatic Sciences·Keita WadaTadahiro Takada
Nov 16, 2014·Journal of Cancer Research and Clinical Oncology·Yousuke NakaiKazuhiko Koike
Jan 31, 2015·Pancreas·Naminatsu TakaharaKazuhiko Koike
Apr 27, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jeong Youp Park
Oct 14, 2018·Medicine·Hong ZhuHongfeng Gou

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