A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer’s Disease and Healthy Controls

Brain Sciences
Daniel J BlackburnPtolemaios G Sarrigiannis

Abstract

The incidence of Alzheimer disease (AD) is increasing with the ageing population. The development of low cost non-invasive diagnostic aids for AD is a research priority. This pilot study investigated whether an approach based on a novel dynamic quantitative parametric EEG method could detect abnormalities in people with AD. 20 patients with probable AD, 20 matched healthy controls (HC) and 4 patients with probable fronto temporal dementia (FTD) were included. All had detailed neuropsychology along with structural, resting state fMRI and EEG. EEG data were analyzed using the Error Reduction Ratio-causality (ERR-causality) test that can capture both linear and nonlinear interactions between different EEG recording areas. The 95% confidence intervals of EEG levels of bi-centroparietal synchronization were estimated for eyes open (EO) and eyes closed (EC) states. In the EC state, AD patients and HC had very similar levels of bi-centro parietal synchronization; but in the EO resting state, patients with AD had significantly higher levels of synchronization (AD = 0.44; interquartile range (IQR) 0.41 vs. HC = 0.15; IQR 0.17, p < 0.0001). The EO/EC synchronization ratio, a measure of the dynamic changes between the two states, also sho...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1986·Electroencephalography and Clinical Neurophysiology·R P BrennerF Boller
Jul 1, 1980·The American Journal of Psychiatry·N HendlerD Long
Mar 1, 1994·Electroencephalography and Clinical Neurophysiology·C BesthornU Schreiter-Gasser
Aug 1, 1994·Electroencephalography and Clinical Neurophysiology·W S PritchardR M Hostetler
Jun 1, 1994·Biological Psychiatry·J J DunkinI A Cook
Sep 22, 1998·Electroencephalography and Clinical Neurophysiology·J JeongS H Han
Sep 22, 1998·Electroencephalography and Clinical Neurophysiology·T LocatelliG Comi
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Jul 16, 2003·Acta Neurologica Scandinavica·C J StamPh Scheltens
Jul 31, 2003·Neuropsychology Review·X DelbeuckF Collette
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Y A L PijnenburgC J Stam
Jun 19, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jaeseung Jeong
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C J StamPh Scheltens
Apr 2, 2005·Nature Reviews. Neuroscience·Alfons Schnitzler, Joachim Gross
Aug 24, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C J Stam
Mar 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·E De Renzi, P Faglioni
Feb 3, 2006·Cerebral Cortex·C J StamPh Scheltens
Feb 8, 2006·Physiological Measurement·D AbásoloJ Poza
Feb 16, 2006·Clinical EEG and Neuroscience·Robert SneddonUtpal Saha
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 18, 2009·Psychiatry Research·William Jonathan McGeownAnnalena Venneri
Nov 9, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ziad SankariAnahita Adeli
Jul 23, 2011·Lancet Neurology·Michela PievaniGiovanni B Frisoni
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Aug 22, 2012·NeuroImage·M Jorge CardosoSebastien Ourselin
Oct 27, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yifan ZhaoPtolemaios G Sarrigiannis
Jun 22, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·F HatzP Fuhr
Jun 26, 2013·IEEE Transactions on Bio-medical Engineering·Yifan ZhaoPtolemaios G Sarrigiannis
Jul 16, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ptolemaios G SarrigiannisMarios Hadjivassiliou
Mar 1, 2014·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Aug 6, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Heinrich GarnReinhold Schmidt
Sep 5, 2014·Nature Reviews. Neuroscience·Cornelis J Stam
Sep 13, 2014·Current Alzheimer Research·Sarah J WakefieldAnnalena Venneri

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