PMID: 8964913May 1, 1996Paper

A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

Journal of Neuroimmunology
B W van OostenC H Polman

Abstract

Multiple sclerosis is probably mainly mediated by T-helper 1 (TH1)-lymphocytes. TH1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Outcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of TH1- and TH2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.

References

Nov 1, 1991·Annals of Neurology·K SelmajA H Cross
Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Nov 1, 1991·Journal of Neuroimmunology·Y Kuroda, Y Shimamoto
Aug 1, 1991·Journal of the Neurological Sciences·N TsukadaK Yone
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·L GuariniP B Fisher
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Sep 30, 1988·Biochemical and Biophysical Research Communications·R M StrieterS L Kunkel
Sep 1, 1989·Journal of Immunological Methods·E BloemenaP T Schellekens
Dec 1, 1989·Annals of Neurology·D M FranciottaG V Melzi d'Eril
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·C P GenainS L Hauser
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Apr 1, 1993·Acta Neurologica Scandinavica·K ImamuraT Marunouchi

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Citations

Jul 20, 2000·Journal of Neuroimmunology·M LiefnerW Brück
Dec 1, 1999·Annals of the Rheumatic Diseases·C LockL Steinman
Mar 21, 2015·Lancet Neurology·Bernhard HemmerThomas Korn
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
May 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G N BisagaI N Barsukov
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·H Dinter

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