A pilot study: longer duration of posttransplant hepatitis C virus therapy may increase the sustained response rate

Transplantation Proceedings
Z KarasuM Kilic

Abstract

Although end of treatment virological responses are similar in posttransplant patients with recurrent chronic hepatitis C virus infection and nontransplant patients, the sustained virological response rate is lower in the posttransplant setting. We investigated the efficacy of a longer duration (3 years) of therapy. Thirteen patients with biopsy-proven recurrent hepatitis C were included in the study. In the first year of therapy, all patients were treated with a standard regimen of interferon alpha 2b 3MU 3 times in a week plus ribavirin (800 to 1000 mg/d). After the availability of pegylated interferon, patients were converted to pegylated interferon (1.5 microg/kg body weight). Hepatitis C virus RNA was evaluated at months 3, 6, 9, 12, 24, 36, and 42. If hepatitis C virus RNA was negative at month 12, the patients continued treatment for 36 months. Hepatitis C virus RNA was negative in six patients at 12 months, including two who became hepatitis C virus RNA negative after 3 months; two, after 6 months; and two, after 12 months of therapy. Those six continued treatment completing 3 years of treatment with a sustained virological response. Four of those six patients with sustained virological response required colony-stimulat...Continue Reading

References

Nov 1, 1989·Seminars in Liver Disease·M Peters
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lennox J JeffersK Rajender Reddy
Oct 27, 2004·Archives of Virology·A M BozdayiO Uzunalimoğlu
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J ThuluvathHwan Y Yoo
Nov 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian L PearlmanSophia Saifee

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