A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection

Journal of Vascular Surgery
Ibrahim AboshadyKamal G Khalil

Abstract

Perioperative infection of an aortic graft is one of the most devastating complications of vascular surgery, with a mortality rate of 10% to 30%. The rate of amputation of the lower limbs is generally >25%, depending on the graft material, the location of the graft and infection, and the bacterial virulence. In vitro studies suggest that an antibiotic-impregnated graft may help prevent perioperative graft infection. In a pilot animal study, we tested a locally developed technique of bonding Dacron aortic grafts with three antimicrobial agents to evaluate the ensuing synergistic preventive effect on direct perioperative bacterial contamination. We surgically implanted a 6-mm vascular knitted Dacron graft in the infrarenal abdominal aorta of six Sinclair miniature pigs. Two pigs received unbonded, uninoculated grafts; two received unbonded, inoculated grafts; and two received inoculated grafts that were bonded with chlorhexidine, rifampin, and minocycline. Before implantation, the two bonded grafts and the two unbonded grafts were immersed for 15 minutes in a 2-mL bacterial solution containing 1 to 2 × 10(7) colony-forming units (CFU)/mL of Staphylococcus aureus (ATCC 29213). Two weeks after graft implantation, the pigs were euth...Continue Reading

References

Feb 1, 1992·The Journal of Surgical Research·T M BergaminiW G Cheadle
Aug 1, 1990·The Journal of Trauma·A L NeyM P Bubrick
May 1, 1986·Journal of Vascular Surgery·P J O'HaraL P Krajewski
Dec 1, 1995·Journal of Vascular Surgery·K D CalligaroD A DeLaurentis
Feb 1, 1996·The Journal of Infectious Diseases·I RaadG P Bodey
Jan 8, 1999·The New England Journal of Medicine·R O DarouicheG Mayhall
Oct 3, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Linda Reilly
Jan 1, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ioannis ChatzinikolaouIssam Raad
Sep 30, 2005·Vascular and Endovascular Surgery·Dale SchmachtDennis Bandyk
Nov 1, 2006·Journal of Cardiac Surgery·Jagdish ButanyChristopher Feindel
Oct 2, 2007·Journal of Vascular Surgery·Isabelle JaverliatJean-Louis Gaillard
Feb 26, 2008·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomoko OshiroAriaki Nagayama
Mar 4, 2008·American Journal of Infection Control·Prabha RamrituNicholas Graves
Sep 9, 2008·Seminars in Vascular Surgery·Dennis F Bandyk
Apr 21, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian S SchwartzHenry F Chambers
May 22, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Hongshan ZhongChuanhai Sun
Nov 30, 2011·Antimicrobial Agents and Chemotherapy·Issam RaadRay Y Hachem

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Citations

Jan 1, 2013·Pathogens·David LebeauxChristophe Beloin
Nov 26, 2015·Journal of Vascular Surgery·Mohammed R MoussavianMichael D Menger
Apr 22, 2014·Journal of Vascular Surgery·Kristofer M Charlton-OuwHazim J Safi
Oct 10, 2013·Journal of Vascular Surgery·Yoshihiro SuematsuMitsuhiro Kawata
Sep 16, 2016·Advanced Drug Delivery Reviews·Amin Omar, Patricia Nadworny
Dec 19, 2016·Journal of Vascular Surgery·Michael S ClemensBrandon W Propper
Sep 4, 2014·Microbiology and Molecular Biology Reviews : MMBR·David LebeauxChristophe Beloin
Aug 10, 2018·Laboratory Animals·Louise K JensenHenrik E Jensen
Jan 1, 2018·Polymers·Fangfang TuJiannan Wang
Aug 18, 2018·Annals of Vascular Diseases·Takuya MiyaharaMasanori Ogiwara
Aug 8, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Carlos A MestresUNKNOWN Hospital Clinic Infective Endocarditis Investigators
Apr 13, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Hozan MuftyInge Fourneau

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