A pilot study of alcohol exposure and pharmacokinetics in women with or without children with fetal alcohol syndrome

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Nathaniel C O KhaoleTing-Kai Li

Abstract

To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children. 10 women who had given birth to FAS children (FAS mothers) and 20 Controls were studied to determine how they metabolize alcohol in a single limited-access quasi-experimental session of voluntary consumption of alcohol. They had free choice in the consumption of any amount of their favourite beverage for approximately 2.5 h, but their drinking was terminated if the breath alcohol concentrations (BrAC) exceeded 150 mg%. BrACs was measured during ethanol consumption and for several hours after, for estimation of alcohol exposure and pharmacokinetics. FAS mothers consumed significantly larger amounts of alcohol, and achieved significantly higher peak BrAC levels than Controls. The rate of decline of alcohol from the circulation (beta-60) showed a 2-fold variation across subjects but there was no significant difference between the two groups. This study did not show any difference in alcohol pharmacokinetics in free-choice drinking by non-pregnant women, who either have given or have never given birth to FAS children. However, mothers of FAS chil...Continue Reading

References

May 11, 1978·The New England Journal of Medicine·S K Clarren, D W Smith
Apr 15, 1976·Biochemical Pharmacology·E Mezey
Sep 1, 1976·Journal of Studies on Alcohol·A J SedmanJ G Wagner
May 1, 1990·Neurotoxicology and Teratology·C D DriscollE P Riley
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·A P StreissguthP D Sampson
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·J R WestJ P Brandt
Nov 1, 1987·Clinical Pharmacokinetics·N H Holford
Jan 1, 1986·Annals of the New York Academy of Sciences·R J SokolS I Miller
Jan 1, 1987·American Journal of Obstetrics and Gynecology·C B ErnhartA Wolf
Mar 1, 1984·Alcoholism, Clinical and Experimental Research·H H Samson, K A Grant
Jan 1, 1980·The American Journal of Clinical Nutrition·P E WatsonR D Batt
Jul 1, 1995·Neurotoxicology and Teratology·E L Abel
Jan 1, 1995·Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism·H R Thomasson
Oct 1, 1994·Drug and Alcohol Dependence·A P StreissguthF L Bookstein
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·A P StreissguthA F Mirsky
May 1, 1996·Alcoholism, Clinical and Experimental Research·J R HankinS S Martier
May 15, 1998·Alcoholism, Clinical and Experimental Research·J L JacobsonJ W Ager
May 8, 2000·Alcoholism, Clinical and Experimental Research·R T Gentry
May 8, 2000·Alcoholism, Clinical and Experimental Research·H Kalant
May 8, 2000·Alcoholism, Clinical and Experimental Research·T K LiH R Thomasson
Dec 9, 2000·American Journal of Public Health·P A MayD Viljoen
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·T K LiV A Ramchandani
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·N SatoV A Ramchandani
Jan 5, 2002·Pathologie-biologie·V A RamchandaniT K Li
Jan 5, 2002·Journal of Clinical Pharmacology·V A RamchandaniT K Li

❮ Previous
Next ❯

Citations

Apr 18, 2013·International Journal of Environmental Research and Public Health·Giorgie Petković, Ingeborg Barišić
May 19, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·L BurdK Dropps
Jun 12, 2013·Journal of Developmental and Behavioral Pediatrics : JDBP·Philip A MayColleen M Adnams
Dec 15, 2015·Reproductive Toxicology·Philip A MayJ Phillip Gossage
Mar 24, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Kenneth R Warren, Ting-Kai Li
Apr 17, 2007·Alcoholism, Clinical and Experimental Research·Marta Yanina PepinoJulie A Mennella
Mar 14, 2008·Alcoholism, Clinical and Experimental Research·Philip A MayDenis L Viljoen
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Philip A MayMauro Ceccanti
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Philip A MaySoraya Seedat
Feb 17, 2015·Alcoholism, Clinical and Experimental Research·Bahri KaracayDaniel J Bonthius
Aug 16, 2006·Neuroscience and Biobehavioral Reviews·Simonetta GemmaEmanuela Testai
Jan 21, 2006·The Journal of Pediatrics·Sandra W JacobsonJoseph L Jacobson
May 6, 2015·Alcoholism, Clinical and Experimental Research·Michael F UrbanMatthew F Chersich
May 26, 2009·BMC Pediatrics·Elizabeth PeadonElizabeth J Elliott
Dec 11, 2014·Fertility and Sterility·Catherine A VandeVoortKeith E Latham
Jan 26, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Berardino PetrelliGeoffrey G Hicks
Sep 25, 2017·Alcoholism, Clinical and Experimental Research·R Colin CarterSandra W Jacobson
Jun 19, 2017·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.