A pilot study of brain activation in children with trichotillomania during a visual-tactile symptom provocation task: a functional magnetic resonance imaging study

Progress in Neuro-psychopharmacology & Biological Psychiatry
J A LeeG H Bahn

Abstract

In order to reveal the etiology and pathophysiology of trichotillomania (TTM), it is necessary to investigate which brain regions are involved in TTM, but limited knowledge exists regarding the neurobiology of TTM and the available functional neuroimaging studies of TTM are little. The purpose of the present study was to investigate the specific brain regions involved in the pathophysiology of TTM with symptom provocation task using functional magnetic resonance imaging (fMRI) for children and adolescents with TTM. Pediatric subjects who met the DSM-IV TR criteria for TTM (n=9) and age-, sex-, handedness-, IQ matched healthy controls (HC) (n=10), ages 9 to 17 years, were recruited for two fMRI experiments; symptom provocation of Visual Only (VO) and Visual and Tactile (VT). They were scanned while viewing two alternating blocks of symptom provocation (S) and neutral (N) movies. Random effects between-group analysis revealed significant activation in left temporal cortex(including middle and superior temporal gyrus), dorsal posterior cingulate gyrus, and putamen for the contrast S>N in TTM subjects versus HC subjects during the VO session. And TTM subjects demonstrated higher activity in the precuneus and dorsal posterior cingul...Continue Reading

References

Sep 1, 1991·Archives of General Psychiatry·S E SwedoC L Grady
Mar 1, 1991·The American Journal of Psychiatry·G A ChristensonJ E Mitchell
Mar 1, 1991·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S E Swedo, J L Rapoport
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jan 1, 1995·Psychotherapy and Psychosomatics·N J KeuthenL Baer
Sep 6, 1996·Science·B J KnowltonL R Squire
Jul 1, 1997·The American Journal of Psychiatry·R D LaneR J Davidson
Jan 4, 1998·Journal of Anxiety Disorders·M A StanleyJ K Breckenridge
Jul 29, 1998·Brain : a Journal of Neurology·C BüchelK J Friston
Oct 1, 1998·Neurobiology of Learning and Memory·A M Graybiel
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jan 6, 2001·Neuron·A M Graybiel, S L Rauch
Aug 3, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Bavanisha VythilingumDan J Stein
Nov 28, 2002·Human Brain Mapping·Richard J MaddockMichael H Buonocore
Dec 9, 2003·Neuron·Allison N McCoyMichael L Platt
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Sep 2, 2006·Biological Psychiatry·Nancy J KeuthenScott L Rauch
Jan 12, 2007·Journal of Psychiatric Research·Antje BohneSabine Wilhelm
Feb 27, 2007·Psychiatry Research·Scott L RauchNancy J Keuthen
Apr 4, 2007·The American Journal of Psychiatry·Samuel R ChamberlainNaomi A Fineberg
Sep 15, 2007·Brain : a Journal of Neurology·Lara MenziesEd Bullmore
Sep 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Samuel R ChamberlainBarbara J Sahakian
May 12, 2009·Neuroscience and Biobehavioral Reviews·Samuel R ChamberlainJon E Grant
Aug 21, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Michael H Bloch

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Citations

Jun 20, 2013·Journal of Psychiatric Research·Matthew P WhiteMichael D Greicius
May 21, 2015·Psychiatry Research·Sarah K Francazio, Christopher A Flessner
Jul 31, 2013·La Presse médicale·Olivier Doumy, Bruno Aouizerate
Oct 3, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Hugues LamotheAntoine Pelissolo
Nov 15, 2016·Case Reports in Psychiatry·Pongsatorn Paholpak, Mario F Mendez
Aug 20, 2021·Brain Imaging and Behavior·Jon E GrantNancy J Keuthen
Nov 4, 2021·CNS Spectrums·Jon E GrantNancy J Keuthen

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