PMID: 16523809Mar 10, 2006Paper

A pilot study of brain tumour growth between radiotherapy planning and delivery

Clinical Oncology : a Journal of the Royal College of Radiologists
C PenningtonJ M Wardlaw

Abstract

Delays between surgery and the delivery of radiotherapy may allow brain tumours to grow beyond the planned radiotherapy fields and therefore reduce the effectiveness of radiotherapy. This pilot study aimed to ascertain whether significant growth of brain tumours occurs between post-biopsy imaging and the start of radiotherapy. Two estimates of tumour volume were obtained from contrast-enhanced magnetic resonance images obtained within 3 days of surgical debulking/biopsy (postoperative), and shortly before starting radiotherapy (pre-radiotherapy). The postoperative and pre-radiotherapy volumes were compared to assess tumour growth and expansion of the tumour margin. The enhancing tumour volume was measured on a workstation using two methods: tracing the area of the lesion on each slice on which it appeared and summing the volume in each slice, and by measuring the largest diameters in three planes. The ease of use and intra-operator variability of the two methods were compared. The median time between postoperative and pre-radiotherapy scans was 31.5 days (range 15-53 days). Both methods found that statistically significant tumour growth occurred between postoperative and pre-radiotherapy imaging. The tumour area method found me...Continue Reading

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Citations

Mar 1, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·K R SwansonE C Alvord
Feb 28, 2007·International Journal of Radiation Oncology, Biology, Physics·Bleddyn Jones, Paul Sanghera
Nov 27, 2015·Healthcare Technology Letters·Kun ChengWilliam H Nailon
Mar 12, 2015·Neuro-oncology·Anne Line StensjøenErik Magnus Berntsen
May 6, 2016·Frontiers in Neuroscience·Emrah Özcan, Tunahan Çakır
Jul 4, 2020·Future Oncology·Dominic J GesslerClark C Chen
Feb 21, 2019·Journal of Neuro-oncology·Amaury De BarrosFranck-Emmanuel Roux
Dec 25, 2012·Journal of Neuro-oncology·Paolo FaraceAlberto Beltramello
Apr 12, 2019·American Journal of Clinical Oncology·Joshua D PalmerWenyin Shi

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