PMID: 7712436May 1, 1995Paper

A pilot study of combination therapy of radiation and local administration of OK-432 for esophageal cancer. Five-year survival and local control rate

Cancer
M MukaiA Akanuma

Abstract

Combination therapy consisting of radiation and local administration of OK-432 was administered to 73 patients with esophageal cancer without distant metastases. Seventy patients were examined. The average age was 71 years. There were 60 males and 10 females. The mean tumor length was 7.0 cm. One mg of OK-432 was administered endoscopically to and around the cancerous lesion at the beginning of radiotherapy and a second dose of 0.5 mg of OK-432 was given in the same manner 2 weeks later. X-ray irradiation was given at a daily dose of 1.6-1.8 Gy, five fractions a week. The average total dose was 61.1 Gy. Complete responses were obtained in 49 of the 70 patients (70.0%), and partial responses (PR) in the remaining 21. The 5-year cause-specific survival rate of the 70 patients was 33.1%. The 5-year survival rate of the 49 patients with CR was 44.9%, and there were no patients with PR who survived more than 2 years. The 5-year survival rate of the 13 patients with T1 (UICC, 1987) was 79.6%, of the 24 patients with T2/3 41.1%, and of the 33 patients with T4 11.6%. The 5-year survival rates of the 18 patients with tumors less than 5 cm in length and the 40 patients with tumors 5 to 10 cm were 59.9 and 37.9%, respectively. In the pati...Continue Reading

References

Jul 1, 1976·Cancer·R D MarksK M Wallace
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M MukaiH Tsunemoto
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M MukaiK Nagao
Dec 1, 1967·Japanese Journal of Microbiology·H OkamotoR Shimizu
Jul 1, 1980·The British Journal of Surgery·R Earlam, J R Cunha-Melo
May 3, 1982·Clinical Radiology·G A NewaishyG R Kerr

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Citations

Apr 19, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y FunamiS Sato
Dec 4, 2001·American Family Physician·R A Koler, A Montemarano
Aug 24, 2006·Japanese Journal of Clinical Oncology·Kiichiro NodaKeiichi Fujiwara
Sep 19, 2018·Molecular Pharmaceutics·Maryam A Shetab Boushehri, Alf Lamprecht

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