A pilot study of contrast harmonic endosonography using DEFINITY™ in the evaluation of suspected pancreatic and peri-ampullary malignancies.

Journal of Interventional Gastroenterology
Tiing Leong AngKwong Ming Fock

Abstract

AIM: Contrast harmonic endosonography (CHEUS) is not widely available. This study assessed the utility of CHEUS using DEFINITY™, a second generation ultrasonic contrast agent, in the evaluation of suspected pancreatic and peri-ampullary malignancies. METHODS: Prospectively enrolled patients with suspected pancreatic and peri-ampullary malignancies underwent EUS followed by CHEUS. The incremental yield of CHEUS over EUS was analyzed. The gold standard for diagnosis of malignancy was positive cytology or histology; a negative diagnosis for malignancy was based on negative cytology or histology and benign clinical course. RESULTS: Twenty-nine patients were enrolled and underwent CHEUS. The final diagnoses were: pancreatic adenocarcinoma (16/29); metastases to pancreas (4/29); pancreatitis with inflammatory mass (4/29); normal pancreas with focal fat sparing (1/29); ampulla adenocarcinoma (2/29); serous cystic neoplasm (1/29); peri-pancreatic lymph node due to lymphoma (1/29). One bengin case of chronic pancreatitis had calcification casting artifacts that prevented accurate EUS examination and was excluded, leaving 28 cases for comparative analysis between EUS and CHEUS. CHEUS enhanced tumor margins. CHEUS detected vascular inva...Continue Reading

Citations

Mar 16, 2013·Journal of Gastroenterology and Hepatology·Pradermchai KongkamUNKNOWN Asian Consortium of EUS
Jul 8, 2015·Journal of Cellular and Molecular Medicine·Liang-Hao HuZhao-Shen Li
Jul 7, 2017·Fukushima Journal of Medical Science·Mitsuru SugimotoHiromasa Ohira
Jan 21, 2017·World Journal of Gastroenterology : WJG·Andrada SeiceanRadu Seicean
Mar 4, 2021·Ultrasound in Medicine & Biology·Masayuki KitanoUNKNOWN Working group for the International Consensus Guidelines for Contrast-Enhanced Harmonic Endoscopic Ultrasound

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