PMID: 9524997Apr 3, 1998Paper

A pilot study of metronidazole vaginal gel versus oral metronidazole for the treatment of Trichomonas vaginalis vaginitis

Sexually Transmitted Diseases
L duBouchetW M McCormack

Abstract

Trichomonas vaginalis is a common sexually transmitted pathogen. In the United States, oral metronidazole is the only officially sanctioned treatment option. This study was undertaken to compare the efficacy and safety of 0.75% metronidazole vaginal gel with that of oral metronidazole for the treatment of trichomonal vaginitis. Women with trichomoniasis were enrolled in this randomized, open-label pilot study of 0.75% metronidazole vaginal gel twice daily for 7 days compared with 7 days of generic oral metronidazole, 250 mg, three times daily. Patients were seen for follow-up visits 5 to 7 days and 21 to 28 days after the last dose of medication. Using culture for test of cure, trichomonal infection was eliminated in all 15 women treated with oral metronidazole and 7 (44%) of 16 women treated with intravaginal metronidazole. Adverse events were similar, except that there were more taste-related adverse events in the oral metronidazole group. Significant reductions in genitourinary symptoms were seen in both the oral and intravaginal groups. This study has shown that 0.75% metronidazole vaginal gel is not effective as a single agent for the treatment of trichomoniasis. Future studies may define a role for metronidazole gel for s...Continue Reading

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Citations

Dec 12, 2012·International Urogynecology Journal·Sushma Srikrishna, Linda Cardozo
Apr 1, 2004·Sexually Transmitted Infections·H SwygardM S Cohen
Mar 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alamdar Hussain, Fakhrul Ahsan
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Sixto SanchezKing K Holmes
Nov 30, 2016·Sexually Transmitted Diseases·Katharine Howe, Patricia J Kissinger
May 26, 2017·Clinical Microbiology Reviews·Kawthar BouchemalPhilippe M Loiseau
May 5, 2000·The Cochrane Database of Systematic Reviews·A M Gülmezoglu, F Forna
Sep 25, 2019·Medical Sciences : Open Access Journal·Aruna Kumari DivakaruniSrinivas Divakaruni
Apr 20, 2002·Current Opinion in Infectious Diseases·Michael W. Lehker, John F. Alderete
Aug 28, 2019·Antimicrobial Agents and Chemotherapy·Anthony J O'DonoghueLars Eckmann
Feb 22, 2014·Expert Review of Anti-infective Therapy·Arlene C SeñaMarcia M Hobbs
Jun 14, 2003·The Cochrane Database of Systematic Reviews·F Forna, A M Gülmezoglu

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