A pilot study of soluble adhesion molecules as surrogate markers for acute liver allograft rejection

Transplantation
V J NavarroJ S Pober

Abstract

Tissue endothelial adhesion molecule expression is increased during acute liver allograft rejection. Soluble forms exist, but their correlation to rejection and their clinical value have not been determined. We studied endothelial adhesion molecule tissue expression and soluble levels in blood and bile and correlated these to the clinical course of 11 adult patients followed for 30 consecutive days after liver transplantation. Three biopsies showing acute rejection demonstrated increased intercellular adhesion molecule (ICAM)-1 but not endothelial leukocyte adhesion molecule-1 expression on hepatic endothelial cells during rejection. Vascular cell adhesion molecule (VCAM)-1 staining was focally increased in two of three specimens. Levels of soluble ICAM-1 or soluble VCAM-1 by ELISA did not distinguish acute rejection from nonrejection conditions. We confirmed that endothelial ICAM-1 expression is more intense in rejecting allografts and is more sensitive than changes in VCAM-1 or endothelial leukocyte adhesion molecule-1. However, soluble adhesion molecule determination was not useful in the accurate detection of acute rejection.

References

Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Martinez
Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D NinovaR H Wiesner

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Citations

Oct 9, 1999·Clinical Transplantation·B BewigJ Cremer
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·M RomeroR Moreno Otero
Aug 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G WeigelM M Müller
Nov 29, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xavier P D VerhelstHans van Vlierberghe
Sep 10, 2005·Journal of Pediatric Surgery·Mark DavenportJ Michael Tredger

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