A pilot study of the association between genetic polymorphisms involved in estrogen signaling and infant male genital phenotypes.

Asian Journal of Andrology
Sheela SathyanarayanaStephen M Schwartz

Abstract

Single nucleotide polymorphisms (SNPs) in genes that influence development of the male reproductive tract have been associated with male genitourinary abnormalities. However, no studies have tested the relationship between SNPs and intermediate phenotypes such as anogenital distance (AGD), anoscrotal distance (ASD) and penile width (PW). We tested whether 24 common SNPs in eight genes that influence male genital development were associated with intermediate phenotypes in 106 healthy male infants from the Study for Future Families. We used DNA from buccal smears and linear regression models to assess the relationship between anogenital measurements and SNP genotypes with adjustment for covariates. We found that the rs2077647 G allele, located in the coding region of estrogen receptor alpha (ESR1), was associated with a shorter AGD (P=0.02; -7.3 mm, 95% confidence interval (CI): -11.6 to -3.1), and the rs10475 T allele, located in the 3' untranslated region of activating transcription factor 3 (ATF3), was associated with a shorter ASD (-4.3 mm, 95% CI: -7.2 to -1.4), although this result was not significant (P=0.07) after controlling for multiple comparisons. We observed no association between PW and the SNPs tested. Minor allele...Continue Reading

References

Nov 14, 1997·Pediatrics·L J PaulozziR J Jackson
Mar 25, 1999·Environmental Health Perspectives·L J Paulozzi
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L E GrayL Parks
Jun 8, 2001·Human Reproduction Update·P M FosterM Sar
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·H N LimJ R Hawkins
Jan 28, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jeanne M Manson, Michael C Carr
Mar 16, 2004·Environmental Research·Kun Suk KimLaurence S Baskin
Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Manori J SilvaAntonia M Calafat
Nov 10, 2004·Urology·Shu FengAlexander I Agoulnik
Aug 5, 2005·Environmental Health Perspectives·Shanna H SwanUNKNOWN Study for Future Families Research Team
Nov 25, 2005·Pediatric Research·Benchun LiuLaurence S Baskin
Feb 3, 2006·Environmental Health Perspectives·Shanna H Swan
Feb 10, 2006·International Journal of Andrology·L Earl GrayLouis Guillette
Feb 10, 2006·International Journal of Andrology·Ted Schettler
Apr 18, 2007·The Journal of Urology·Zhong WangLaurence S Baskin
Apr 18, 2007·The Journal of Urology·Brahim El HouateKen McElreavey
May 8, 2007·Nature Clinical Practice. Urology·Emily Willingham, Laurence S Baskin
Jun 21, 2007·The Journal of Clinical Endocrinology and Metabolism·Ana Beleza-MeirelesAgneta Nordenskjöld
Nov 23, 2007·Human Reproduction Update·H E Virtanen, J Toppari
Apr 15, 2008·Dementia and Geriatric Cognitive Disorders·Nicole SchupfWayne Silverman
Apr 19, 2008·Current Urology Reports·Michael H HsiehLaurence S Baskin
Apr 23, 2008·European Journal of Endocrinology·Ana Beleza-MeirelesAgneta Nordenskjöld
May 2, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan MillUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Sep 23, 2008·The Journal of Urology·Nicolas KalfaLaurence S Baskin
Dec 3, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Tomoko SonodaHideyuki Akaza
Apr 13, 2010·Pathology Oncology Research : POR·Andrei AnghelLiviu Tamas
Jun 15, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Katharina M MainJorma Toppari
Jul 6, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Mohammad Reza SafarinejadShiva Safarinejad

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Citations

Feb 6, 2016·Andrology·A ThankamonyI A Hughes
Feb 16, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Camilla Lindgren SchwartzTerje Svingen
Jan 15, 2015·Journal of Developmental Origins of Health and Disease·E S BarrettS H Swan

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