A pilot study of the prevalence of psychiatric disorders in PLS and ALS.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Edward D HueyMary Kay Floeter

Abstract

The prevalence of psychiatric disorders in primary lateral sclerosis (PLS) is currently unknown. In the present study, we compared the prevalence of psychiatric illness in patients with PLS and amyotrophic lateral sclerosis (ALS). We hypothesized that if the psychosocial stress of motor neuron disease predisposes patients to depressive disorders, patients with ALS (with a poorer prognosis and more disability than patients with PLS) should have a higher prevalence of depressive disorders than patients with PLS. We administered the gold standard of psychiatric assessment, the SCID, to 19 PLS and 13 ALS patients. We found a prevalence of current depressive disorders in PLS patients that was, by a non-significant trend, lower than that of ALS patients. The prevalence of current depressive disorders in the ALS patients was higher than previously reported and similar to that observed in non-neurological medical disorders. Other psychiatric disorders were rare. In conclusion, depressive disorders were the most commonly observed psychiatric disorders in both PLS and ALS. By a non-significant trend, the PLS patients had a lower current prevalence of depressive disorders than the ALS patients. These data are consistent with the hypothesi...Continue Reading

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Citations

Dec 9, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Judith G RabkinUNKNOWN Als Cosmos Study Group
Mar 24, 2016·Trends in psychiatry and psychotherapy·Tatiana Lins CarvalhoCarolina da Cunha Correia
Jul 27, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Bálint S de VriesMichael A van Es
Dec 25, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Lucas M T BrancoMarcondes C FranÇa
Apr 3, 2021·Journal of Affective Disorders·Mohammad Eghbal HeidariAlireza Gharebaghi

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