A pilot study of the teratogenicity of vagus nerve stimulation in a rabbit model

Brain Stimulation
Ingela Danielsson, Laurence Lister

Abstract

Vagus nerve stimulation (VNS) is approved for the adjunctive treatment of both refractory epilepsy and treatment-resistant depression. This study assessed the effect of VNS on fertility, teratogenicity, and neonatal morbidity in rabbits. Ten female New Zealand white rabbits (test animals) were implanted with the VNS device. Ten additional female rabbits (surgical controls) received nonfunctional devices. Four additional female rabbits served as untreated controls and 10 male rabbits served for siring purposes. Test rabbits received VNS at 1 mA, 30 Hz, 500 microseconds, 30 seconds ON, 5 minutes OFF. Rabbits mated and were randomly assigned into 2 groups: those killed on day 28 and those proceeding through parturition. Groups were compared by using a 1-way analysis of variance with a Newman-Keuls Multiple Comparison post-hoc test. Differences between control and test animals were considered statistically significant if P </= .05. No statistically significant differences were noted for weight, matings required for successful copulation, food or water consumption, hematology, clinical chemistry, organ weights, uterine contents, kit weights and survival, or clinical observations. No changes or abnormalities could be attributed to th...Continue Reading

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Citations

Nov 3, 2012·Epilepsy Currents·Elinor Ben-Menachem
Sep 12, 2015·Brain Stimulation·Alisson Paulino TrevizolPedro Shiozawa
Jun 1, 2017·Acta Neurologica Scandinavica·X Rodríguez-OsorioM Carreño
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Jul 6, 2013·Archives of Women's Mental Health·Thalia K Robakis, Katherine Ellie Williams
May 23, 2021·Epilepsy Research·Jiangwei DingTao Sun
Sep 9, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Jan ChrastinaMilan Brazdil

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