A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): A structured summary of a randomized controlled trial study protocol

Trials
Fahad FaqihiDimitrios Karakitsos

Abstract

To evaluate the safety of therapeutic plasma exchange (TPE) in adult patients with serious/life-threatening COVID-19 requiring intensive care unit (ICU) admission, and associated 28-day mortality. Serious and life threatening COVID-19 are defined as per published literature (please, refer to the full protocol, Additional file 1). The rationale is that TPE can remove interleukins-3, 6, 8, 10, interferon-gamma and tumor necrosis factor-alpha. Thus, it may reduce the cytokine release syndrome associated with fulminant COVID-19 disease. Pilot, interventional, open-label, randomized controlled multicenter trial. Inclusion criteria are: 1) age ≥ 18 years old; 2) intubation and intensive care unit (ICU) admission; 3) serious and/or life-threatening COVID-19 (please, refer to the full protocol, Additional file 1). SARS-CoV-2 infection is confirmed by Real-Time-Polymerase-Chain-Reaction (RT-PCR) assays using QuantiNova Probe RT-PCR kit (Qiagen) in a Light-Cycler 480 real-time PCR system (Roche, Basel, Switzerland). Exclusion criteria are: 1) previous allergic reaction to plasma exchange or its ingredients (i.e., sodium citrate), 2) two consecutive negative RT-PCR tests for SARS-CoV-2 at least 24 hours apart, 3) mild COVID-19 not requiri...Continue Reading

Citations

Aug 8, 2020·Journal of Medical Virology·Fahad FaqihiDimitrios Karakitsos
Dec 29, 2020·International Journal of Antimicrobial Agents·Ziad A MemishDimitrios Karakitsos
Apr 11, 2021·International Journal of Antimicrobial Agents·Fahad FaqihiZiad A Memish
Jun 9, 2021·Journal of Clinical Immunology·Donald C VinhUNKNOWN COVID Human Genetic Effort
Jul 31, 2021·Journal of Hazardous Materials·Xiao ChenYingjun Yu
Aug 15, 2021·Advances in Chronic Kidney Disease·Amber P Sanchez, Rasheed A Balogun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Faryal KhamisZiad Memish
© 2022 Meta ULC. All rights reserved