A pilot study of transcatheter arterial interferon embolization for patients with hepatocellular carcinoma

Cancer
Man-Fung YuenChing-Lung Lai

Abstract

Systemic, high-dose interferon-alpha treatment given three times per week subcutaneously induces tumor regression in approximately 30% of patients with inoperable hepatocellular carcinoma (HCC). The objective of the current study was to determine the efficacy and safety of transcatheter arterial interferon embolization for the treatment of patients with inoperable HCC. Eighteen patients with inoperable HCC were recruited to receive 3 different doses of interferon-alpha-2b (10 megaunits [MU]/m(2), 30 MU/m(2), or 50 MU/m(2)) at intervals of 8-12 weeks. Their tumor response, adverse events, and survival were monitored. In 14 patients with nondiffuse HCC, complete responses and partial responses (> 50% tumor reduction) were observed in 28.6% and 35.7% of patients, respectively. One of four patients with diffuse HCC had a partial response. Thirty-eight percent of patients had normalization of their alpha-fetoprotein level. The median ferritin level at the last follow-up was reduced significantly (765 pmol/L; range, 457-2720 pmol/L) compared with the baseline level (1980 pmol/L; range, 1100-3300 pmol/L; P = 0.011). The median survival was 15.9 months. Transient fever and rigor were the most common side effects observed. Five patients...Continue Reading

References

Dec 1, 1987·Scandinavian Journal of Gastroenterology·A A DunkH C Thomas
May 11, 1995·The New England Journal of Medicine·UNKNOWN Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L LaiH J Lin
May 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·H NganW K Tso
Feb 12, 1998·Thyroid : Official Journal of the American Thyroid Association·L K KohP P Yeo
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong

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Citations

Apr 7, 2004·Current Oncology Reports·Beatrice Gerard, Harry Bleiberg
Aug 30, 2008·Surgical Oncology Clinics of North America·Akira Yamamoto, Takami Sato
Jan 24, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hua ZhaoXiubao Ren
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Bazarragchaa DamdinsurenMorito Monden

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