A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Aminah JatoiCharles L Loprinzi

Abstract

Weight loss predicts a poor prognosis for patients with non-small-cell lung cancer. Tumor necrosis factor alpha (TNFalpha) is a mediator of this weight loss, yet no studies have tested infliximab, an IgG monoclonal antibody that blocks the binding of TNFalpha to its p55 and p75 receptors, for this indication. The safety and pharmacokinetics of infliximab in combination with docetaxel, a commonly used chemotherapy agent for non-small-cell lung cancer, were explored in this pilot study. Four patients with metastatic non-small-cell lung cancer were treated initially with infliximab 5 mg/kg per day intravenously once a week on weeks 1, 3 and 5, and docetaxel 36 mg/m2 per day intravenously once a week on weeks 1, 2, 3, 4, 5 and 6 of an 8-week treatment cycle. Therapy was well tolerated with no grade 4 or 5 adverse events. Maximal serum concentrations of infliximab at 1, 3 and 5 weeks were (mean+/-SD) 108+/-11, 135+/-19, and 139+/-6 microg/ml, respectively, and appeared similar to historical concentrations from non-cancer patients not receiving concomitant chemotherapy (144+/-68 microg/ml). One patient manifested weight stability. One patient manifested a partial tumor response, one stable disease, and two disease progression. Median...Continue Reading

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Citations

Mar 26, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·James D HarrisonMichael J Solomon
May 1, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lenka A TaylorUlrich Massing
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Nov 10, 2006·Annals of Surgical Oncology·Maurizio BossolaGiovan Battista Doglietto
Aug 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aminah JatoiCharles L Loprinzi
Apr 20, 2007·BJU International·Jeffrey S TurnerDavid I Quinn
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