Abstract
Weight loss predicts a poor prognosis for patients with non-small-cell lung cancer. Tumor necrosis factor alpha (TNFalpha) is a mediator of this weight loss, yet no studies have tested infliximab, an IgG monoclonal antibody that blocks the binding of TNFalpha to its p55 and p75 receptors, for this indication. The safety and pharmacokinetics of infliximab in combination with docetaxel, a commonly used chemotherapy agent for non-small-cell lung cancer, were explored in this pilot study. Four patients with metastatic non-small-cell lung cancer were treated initially with infliximab 5 mg/kg per day intravenously once a week on weeks 1, 3 and 5, and docetaxel 36 mg/m2 per day intravenously once a week on weeks 1, 2, 3, 4, 5 and 6 of an 8-week treatment cycle. Therapy was well tolerated with no grade 4 or 5 adverse events. Maximal serum concentrations of infliximab at 1, 3 and 5 weeks were (mean+/-SD) 108+/-11, 135+/-19, and 139+/-6 microg/ml, respectively, and appeared similar to historical concentrations from non-cancer patients not receiving concomitant chemotherapy (144+/-68 microg/ml). One patient manifested weight stability. One patient manifested a partial tumor response, one stable disease, and two disease progression. Median...Continue Reading
References
Jul 4, 1990·Journal of the National Cancer Institute·C L LoprinziL H Geeraerts
Apr 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E RappA M Arnold
Dec 1, 1988·American Journal of Clinical Oncology·D M FinkelsteinJ M Wolter
May 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M FinkelsteinJ C Ruckdeschel
Apr 1, 1994·Annals of Surgery·J S FalconerD C Carter
Oct 9, 1997·The New England Journal of Medicine·S R TarganP J Rutgeerts
Sep 29, 1998·Arthritis and Rheumatism·R N MainiM Feldmann
Oct 23, 1998·Molecular and Cellular Endocrinology·M LloveraJ M Argiles
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L LoprinziB J Christensen
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Feb 17, 2000·Journal of the National Cancer Institute·H J AgtereschJ H Wilson
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ShepherdJ Berille
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eduardo BrueraVickie Baracos
Jun 11, 2003·Circulation·Eugene S ChungUNKNOWN Anti-TNF Therapy Against Congestive Heart Failure Investigators
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lance C PagliaroColin P Dinney
Jul 29, 2003·Journal of Cancer Research and Clinical Oncology·Branislav JeremicJasna Aleksandrovic
Citations
Mar 26, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·James D HarrisonMichael J Solomon
May 1, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lenka A TaylorUlrich Massing
Apr 11, 2006·Annual Review of Nutrition·Vickie E Baracos
Nov 10, 2006·Annals of Surgical Oncology·Maurizio BossolaGiovan Battista Doglietto
Aug 18, 2006·European Journal of Endocrinology·T J CawoodD O'Shea
Aug 12, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aminah JatoiCharles L Loprinzi
Apr 20, 2007·BJU International·Jeffrey S TurnerDavid I Quinn
Sep 4, 2007·Journal of Clinical Pharmacology·Kathleen Seitz, Honghui Zhou
Mar 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Li YanMarian T Nakada
Jul 20, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rui JuDechang Zhang
Feb 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Livia BianconeFrancesco Pallone
Aug 5, 2010·Inflammatory Bowel Diseases·Livia BianconeFrancesco Pallone
Nov 28, 2017·Journal of Managed Care & Specialty Pharmacy·Edward Li, Ernesto Lobaina
Aug 26, 2011·Palliative Medicine·Anke RiesLukas Radbruch
Jun 11, 2005·Current Oncology Reports·Karin F Giordano, Aminah Jatoi
Jul 7, 2007·Head & Neck·Victor LaiMarion Couch
Jul 28, 2007·Clinical Pharmacokinetics·Ulrich KlotzMatthias Schwab
Aug 4, 2007·Cancer·Aminah JatoiCharles L Loprinzi
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Florian Strasser
Apr 8, 2006·The American Journal of Clinical Nutrition·John E MorleyMargaret-Mary G Wilson
Feb 8, 2007·Head & Neck·Marion CouchCarol Shores