Abstract
A challenge is the recommended test to diagnose cow's milk protein allergy. However, many parents and physicians prefer to not challenge because the procedure may cause (severe) symptoms. In clinical routine, diagnostic testing is only available for IgE-mediated allergy. The aim of this study was to test the diagnostic accuracy of a symptom-based score to select infants at risk of having cow's milk protein allergy. A symptom-based score was developed and consensus was reached that a score of ≥12 would select infants at risk of cow's milk protein allergy. Diagnosis of cow's milk protein allergy was demonstrated with a positive challenge after 1-month elimination diet. An open challenge was performed in 85/116 (73%) infants suspected of cow's milk protein allergy based on a symptom-based score ≥ 12 and was positive in 59/85 (69%). Although "a challenge test" was planned in the protocol, 27% of the parents refused the challenge. The mean decrease after 1 month of elimination diet with an extensive hydrolysate was -8.07 (95% confidence interval = -8.74, -7.40). If the symptom-based score during the elimination diet decreased to 6 or lower, 80% of the infants had a positive challenge test. If the symptom-based score remained >7, the...Continue Reading
References
May 15, 2001·Allergy·M EggesbøP Magnus
Feb 28, 2002·The Journal of Pediatrics·Timo KlemolaElina Varjonen
Aug 31, 2004·International Journal of Epidemiology·Adrian G BarnettAnnette J Dobson
Jul 14, 2007·The Journal of Allergy and Clinical Immunology·Roberto J RonaCharlotte Madsen
Sep 27, 2007·Archives of Disease in Childhood·Yvan VandenplasChristophe Dupont
Jul 14, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Alessandro FiocchiUNKNOWN World Allergy Organization (WAO) Special Committee on Food Allergy
Dec 8, 2010·The Journal of Allergy and Clinical Immunology·Joshua A BoyceUNKNOWN NIAID-Sponsored Expert Panel
Jan 18, 2011·The Journal of Allergy and Clinical Immunology·Scott H Sicherer
Jul 21, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Bastiaan SchoutenJohan Garssen
May 10, 2012·Journal of Pediatric Gastroenterology and Nutrition·S KoletzkoUNKNOWN European Society of Pediatric Gastroenterology, Hepatology, and Nutrition
Aug 14, 2012·Acta Paediatrica·Yvan VandenplasHugo S A Heymans
Citations
Nov 8, 2018·Asia Pacific Allergy·Rajniti PrasadFahmina Anwar
Oct 11, 2019·Nutrients·Silvia SalvatoreMassimo Agosti
Feb 29, 2020·Immunity, Inflammation and Disease·Vincenzo FierroJesus Jiménez
Jul 20, 2016·BMC Pediatrics·Christophe DupontRoberto Berni-Canani
Apr 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Christophe DupontMarie-José Butel
Apr 22, 2014·Pediatric Gastroenterology, Hepatology & Nutrition·Yvan VandenplasThierry Devreker
Jun 11, 2014·Archives of Disease in Childhood·Yvan VandenplasUNKNOWN Paradice Study Group
Apr 12, 2014·European Journal of Pediatrics·Yvan VandenplasUNKNOWN Paradice Study Group
Jan 6, 2015·Acta Paediatrica·Yvan VandenplasAndrea Von Berg
Jul 19, 2018·PloS One·Yvan VandenplasKoen Huysentruyt
Mar 25, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Karolina BigorajskaHania Szajewska
Dec 7, 2018·Allergologia et immunopathologia·Seda Sirin KoseO Karaman
Jan 21, 2021·Nutrients·Mauro CalvaniElisabetta Veronelli
Jan 5, 2021·Journal of Pediatric Gastroenterology and Nutrition·Ana Muñoz-UrribarriYovani M Condorhuamán
May 11, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Georgina ThompsonChristopher Hyde
Jul 29, 2021·Pediatric Gastroenterology, Hepatology & Nutrition·Anna Kozłowska-JalowskaHania Szajewska