A pilot study on the effects of Aroclor 1254 ingestion by rhesus and cynomolgus monkeys as a model for human ingestion of PCBs

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D L ArnoldR Stapley

Abstract

A pilot study using female cynomolgus (Macaca fascicularis) and female rhesus (Macaca mulatta) monkeys was conducted to study the effects of chronic ingestion of polychlorinated biphenyls (PCBs). Four control and four treated monkeys of each species received an apple juice-gelatin mixture containing 0 and 280 micrograms Aroclor 1254/kg body weight/day, respectively, 5 days/wk. The cynomolgus monkeys, which were mature monkeys with a poor breeding history, were treated for approximately 55 wk, while the rhesus monkeys, which were just attaining sexual maturity, were treated for approximately 120 wk. After 38 wk on test, the treated and control rhesus monkeys were mated with untreated males. The clinical signs resulting from the Aroclor 1254 ingestion were similar for both species, and the time of onset after initiation of treatment was not appreciably different between the two species. Several treatment and interspecies differences were found with regard to the haematological and serum biochemistry parameters monitored, but age differences between the two species may have contributed to these findings. Periodic analysis of adipose tissue, blood and faecal specimens for PCBs suggested that the rhesus monkey retained more of the i...Continue Reading

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Citations

Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldK Karpinski
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldJ R Tanner
Jun 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Hayward
Jul 26, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Hayward
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