A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial

Journal of the American Society of Hypertension : JASH
Magdalena MaderoLaura G Sánchez-Lozada

Abstract

Fructose and sodium intake have been associated with hypertension and metabolic syndrome. Although various mechanisms are involved, fructose causes hypertension partly through rising intracellular and serum uric acid. To date, there are no studies in adults that have evaluated the impact of low fructose diets and allopurinol on prehypertensive and overweight subjects. The objective of this study was to compare the effect of low fructose diet and allopurinol or placebo on blood pressure (BP) and metabolic syndrome components The study was a controlled clinical trial and consisted of two phases; in the first phase of intervention (4 weeks), patients were randomized to either low fructose diet (34 patients) or control diet (38 patients). In the second phase of intervention (weeks 4-8), the same groups continued with the same diet prescriptions but were further randomized to receive placebo or allopurinol (300 mg/d). Clinic and 24-hour ambulatory BP, anthropometric measures, and laboratory data were determined at baseline, weeks 4 and 8. Seventy-two patients were included in the trial. At the end of the dietary phase, both diet groups significantly reduced their BP, but there were no between-group differences. Compared to placebo, ...Continue Reading

References

Sep 1, 1966·The New England Journal of Medicine·P J CannonJ H Laragh
Aug 6, 2003·Hypertension·Daniel I Feig, Richard J Johnson
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Robert W PowersJames M Roberts
Mar 8, 2006·Hypertension·Jung Eun LeeHa Young Oh
Jul 11, 2007·Journal of Hypertension·Shirmila SyamalaAnoop Shankar
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson
Jun 11, 2009·Journal of Hypertension·Jun LiangLu Qi
Dec 24, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S E Perez-PozoJ López Lillo
Apr 15, 2011·Metabolism: Clinical and Experimental·Carlos A Roncal-JimenezRichard J Johnson
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Mehmet KanbayRichard J Johnson
May 2, 2012·Hypertension·Magdalena MaderoRichard J Johnson
Sep 26, 2012·Hypertension·Beth Soletsky, Daniel I Feig
Jan 4, 2013·The Journal of Clinical Hypertension·Osman TurakMehmet Kanbay

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Citations

Dec 26, 2015·European Journal of Internal Medicine·Mehmet KanbayRichard J Johnson
Jul 20, 2016·Oxidative Medicine and Cellular Longevity·José Pedraza-ChaverriAlexandra Scholze
Apr 20, 2017·Nutrients·Cristiana CalicetiArrigo F G Cicero
Dec 13, 2016·Current Opinion in Rheumatology·Maartje C CleophasLeo A B Joosten
Oct 21, 2017·Therapeutic Advances in Endocrinology and Metabolism·Cesar I Elizalde-BarreraAlberto F Rubio-Guerra
Sep 3, 2020·The Cochrane Database of Systematic Reviews·Pedro Henrique França Gois, Edison Regio de Moraes Souza
Apr 14, 2017·The Cochrane Database of Systematic Reviews·Pedro Henrique França Gois, Edison Regio de Moraes Souza
Aug 9, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Feb 14, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yang WangJian-Jun Mu
Jul 4, 2020·Annals of Pediatric Endocrinology & Metabolism·Myung Hyun ChoJung Sub Lim
Mar 18, 2020·American Journal of Hypertension·Laura G Sanchez-LozadaRichard J Johnson
Oct 8, 2020·Antioxidants·Alessandra BarbieraBianca Maria Scicchitano
Jan 28, 2021·Journal of Clinical Medicine·Federica PianiClaudio Borghi

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