A pilot study on the use of wet wraps in infants with moderate atopic eczema

Clinical and Experimental Dermatology
P E Beattie, M S Lewis-Jones

Abstract

Wet wrap therapy (WWT) is a well-established treatment for severe atopic dermatitis (AD). However little evidence exists to justify widespread use in the community for less severe eczema. We compared the efficacy of WWT with a standard regime of hydrocortisone, to control moderate AD in children. We carried out a single-observer, randomized, controlled pilot study in 19 children under 5 years of age, with AD of 30% or more body surface area, using only 1% hydrocortisone (HC) prior to the study. Group one applied HC once in the morning for 2 weeks, with wet wraps twice daily for week 1, but only at night for week 2. Group two applied HC twice daily without wet wraps. Both applied emollient twice daily and as necessary. The primary outcome measure was the Six Area, Six Sign Atopic Dermatitis (SASSAD) severity score, and the secondary outcome measures were the Infants Dermatology Quality of Life Index (IDQOL), the Dermatitis Family Impact (DFI) score and the weight of topical steroids and emollients used. Over the 2-week active therapy period the mean fall in SASSAD was 8 [95% confidence interval (CI), -18 to +2; P = 0.11] more in the non-WWT group, the median change in the IDQOL was 2 for Group one and 7 for Group two (95% CI for...Continue Reading

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Citations

Jan 20, 2012·Pediatric Dermatology·Arjan C A Devillers, Arnold P Oranje
Aug 9, 2006·International Journal of Clinical Practice·S Lewis-Jones
Nov 23, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Laurence Le CleachOlivier Chosidow
Jul 16, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Noreen Heer NicolMary D Klinnert
Mar 5, 2016·Italian Journal of Pediatrics·Elena GalliLawrence F Eichenfield
Jun 15, 2005·Clinical and Experimental Dermatology·M J SladdenA M Milligan
Apr 15, 2015·Clinical Reviews in Allergy & Immunology·Melanie Chong, Luz Fonacier
Nov 20, 2016·The British Journal of Dermatology·G González-LópezP Herranz-Pinto
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Dec 4, 2016·American Journal of Clinical Dermatology·Julia K GittlerSeth J Orlow
May 20, 2005·British Journal of Nursing : BJN·Barbara Page

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