A pilot study to profile salivary angiogenic factors to detect head and neck cancers

BMC Cancer
L van der MerweChamindie Punyadeera

Abstract

Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProTM assays. We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers). High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR. We have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC.

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Citations

Oct 11, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Xi ZhangChamindie Punyadeera
Jan 29, 2020·Expert Review of Molecular Diagnostics·José M AmenábarChamindie Punyadeera
Feb 16, 2021·Clinical and Experimental Otorhinolaryngology·Uzdan Uz, Görkem Eskiizmir
May 23, 2021·Molecular Biology Reports·Yunxia WanChamindie Punyadeera
Jul 30, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Morgan CarltonLeila Cuttle

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Software Mentioned

GraphPad Prism
Plex [UNK]
GraphPad
Bio
R package “ corrgram
R
Plex manager

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