A pituitary metastasis, an adenoma and potential hypophysitis: A case report of tumour to tumour metastasis in the pituitary

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Mendel Castle-KirszbaumTony Goldschlager

Abstract

Tumour to tumour metastasis is a rare event, especially in the pituitary. Metastases to pituitary adenomas most commonly occurs in late stage disease, commonly presenting with visual field defects and adenohypophyseal dysfunction. The most frequent primary cancers are lung, breast and renal carcinoma which deposit most commonly in prolactinomas, somatotropinomas, gonadotropinomas. In nearly 40% of cases, sellar symptoms are the harbinger to the diagnosis of primary malignancy. The abnormal vascularity and growth promoting microenvironment of pituitary adenomas may encourage metastatic seeding and proliferation of these "collision tumours". Here, we present a case of a breast carcinoma metastasis to a pituitary null-cell adenoma in the setting of immunotherapy. Infundibular thickening in the setting of immunotherapy is often ascribed to hypophysitis, but our case highlights that metastatic spread should be part of the differential diagnosis.

References

Jan 1, 1989·British Journal of Neurosurgery·P C McCormickA P Hays
Feb 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·S J Mörk, L J Rubinstein
Oct 1, 1988·Surgical Neurology·K D PostA G Kandji
Sep 1, 1988·Experimental and Clinical Endocrinology·J A RamsayM H Weiss
Mar 1, 1974·Radiology·D F PowellE R Laws
Jan 1, 1981·Acta neurochirurgica·V M JoglekarC G Blakeney
Aug 23, 2001·Surgical Neurology·P BretJ Trouillas
Dec 18, 2001·Annals of Diagnostic Pathology·C NogaM Mayberg
Jul 13, 2002·Endocrine Pathology·Ricardo V. LloydLucia Stefaneanu
Jul 13, 2002·Endocrine Pathology·Marek PawlikowskiMaria Jaranowska
Mar 13, 2003·Acta neurochirurgica·J WeberA Spring
Apr 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Onder OnguruRicardo V Lloyd
May 12, 2007·Brain Pathology·Shih-Ming JungTseng-tong Kuo
Aug 25, 2009·Central European Neurosurgery·A HoelligR A Kristof
Jun 13, 2012·International Journal of Surgical Pathology·Fabio RotondoDavid Munoz
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Eric MonsalvesGelareh Zadeh
Aug 1, 2014·Ultrastructural Pathology·Francesca MagnoliCarlo Capella
Nov 29, 2014·International Journal of Endocrinology·Shingo TakanoAkira Matsumura
Dec 17, 2014·International Journal of Endocrinology·Carolina CristinaDamasia Becu-Villalobos
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Le MinUrsula B Kaiser
Jul 6, 2018·Pituitary·Mendel Castle-KirszbaumJames King

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Citations

Aug 20, 2021·Neurosurgery·Mendel Castle-KirszbaumTony Goldschlager
Sep 25, 2021·Journal of Neuropathology and Experimental Neurology·B K Kleinschmidt-DeMasters

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