PMID: 8942892Nov 1, 1996Paper

A placebo-controlled, double-masked evaluation of mitomycin C in combined glaucoma and cataract procedures

Ophthalmology
J S CohenB E Wind

Abstract

This study was performed to determine if adjunctive use of mitomycin C (MMC) would increase the success of combined phacoemulsification, intraocular lens implantation, and trabeculectomy surgery with releasable sutures. Seventy-two eyes with cataract and glaucoma, requiring surgery for decreased vision, uncontrolled intraocular pressure, or to obtain a better view of the optic nerve, were randomized to receive a 2.5-minute subconjunctival exposure to either MMC (0.5 mg/ml) or placebo balanced salt solution. Postoperative evaluations at 3, 6, and 12 months were performed by a masked observer who recorded visual acuity, intraocular pressure, glaucoma medications, presence of filtering blebs, and complications. Endothelial cell counts were measured before and 3 months after surgery. The MMC group had significantly greater reduction in mean intraocular pressure through the first 12 months of follow-up (7.05-7.65 mmHg versus 2.62-3.84 mmHg; P = 0.001-0.028). In addition, through the first 6 months of follow-up, the MMC group required significantly fewer medications (0.4-0.5 versus 1.1-1.2; P = 0.002-0.004). Requirements for additional glaucoma surgery were less in the MMC group (4/ 36) than in the placebo group (7/35) (P = 0.301). F...Continue Reading

References

Jan 1, 1990·Journal of Ocular Pharmacology·C W ChenC C Lee
Sep 15, 1987·American Journal of Ophthalmology·J M RudermanD E Shoch
Apr 1, 1984·Archives of Ophthalmology·R A Lewis, C D Phelps
Jan 1, 1981·Journal - American Intra-Ocular Implant Society·D M ColvardB Davidson
Jul 1, 1995·The British Journal of Ophthalmology·P T Khaw
Apr 1, 1994·Archives of Ophthalmology·M L McDermottD H Shin
Nov 1, 1993·Journal of Cataract and Refractive Surgery·L E Probst, B D Nichols
Jan 1, 1994·Archives of Ophthalmology·A E KolkerJ L Rait
Jan 1, 1994·Archives of Ophthalmology·A K HutchinsonC K Bradley
Mar 1, 1993·Archives of Ophthalmology·M A JohnstoneC J Ziel
Jan 1, 1993·Journal of Glaucoma·H MietzG K Krieglstein

❮ Previous
Next ❯

Citations

May 15, 2003·Survey of Ophthalmology·Paul J Lama, Robert D Fechtner
Aug 31, 1999·Survey of Ophthalmology·C E Margo
Dec 28, 1999·Journal of Cataract and Refractive Surgery·A CaporossiA Balestrazzi
Jan 26, 2000·Journal of Cataract and Refractive Surgery·R Donoso, A Rodríguez
Oct 28, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhong-Jie LinXiao-He Lu
Dec 28, 1999·The British Journal of Ophthalmology·M R WilkinsP T Khaw
Jan 26, 2000·Journal of Cataract and Refractive Surgery·J Y NevyasR Choe
Oct 17, 2012·Survey of Ophthalmology·Leonard K SeiboldMalik Y Kahook
Sep 9, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Nariman NassiriGholam A Peyman
Oct 20, 2006·American Journal of Ophthalmology·Un-Chul ParkHyeong Gon Yu
Apr 1, 2005·Acta Ophthalmologica Scandinavica·J A MaquetN Laguna
Jul 9, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·John S CohenJeffrey M Zink
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Mi Sun SungSang Woo Park
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Akiko FutakuchiHidenobu Tanihara
Oct 20, 2005·The Cochrane Database of Systematic Reviews·M WilkinsR Wormald
Oct 16, 2009·Current Opinion in Ophthalmology·Gianmarco Vizzeri, Robert N Weinreb
May 24, 2013·Seminars in Ophthalmology·Jeffrey R SooHooMalik Y Kahook
Oct 26, 2005·Journal of Cataract and Refractive Surgery·Ettore FerrariFrancesca Menchini
Jan 10, 2001·Current Opinion in Ophthalmology·A Storr-Paulsen, P Bernth-Petersen
Jul 1, 1999·Current Opinion in Ophthalmology·T W Samuelson
Mar 11, 2006·Drugs·Lekha M AbrahamIgal Leibovitch
May 27, 2020·European Journal of Ophthalmology·Ali OlgunS Yekta Sendul
Apr 28, 2009·European Journal of Ophthalmology·Mehmet Baykara, Ozgur Timucin
Jan 25, 2003·Annals of Plastic Surgery·Richard SimmanFrances Williams
May 24, 2020·Scientific Reports·Katherine Watkins GreesonCharles A Easley
Nov 7, 2015·The Cochrane Database of Systematic Reviews·Emily CabourneJennifer R Evans
Jan 12, 2021·Clinical & Experimental Ophthalmology·John SwoggerCecelia C Yates
Aug 19, 2010·Journal of Glaucoma·Ahmed M Emarah, Mostafa Aly El-Helw
May 1, 2014·Journal of Current Glaucoma Practice·Jennifer L JungMalik Y Kahook
Jul 25, 2007·Journal français d'ophtalmologie·A LabbéC Baudouin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.