A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.

American Journal of Respiratory and Critical Care Medicine
Imre NothIdiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet)

Abstract

Animal and human studies support the importance of the coagulation cascade in pulmonary fibrosis. In a cohort of subjects with progressive idiopathic pulmonary fibrosis (IPF), we tested the hypothesis that treatment with warfarin at recognized therapeutic doses would reduce rates of mortality, hospitalization, and declines in FVC. This was a double-blind, randomized, placebo-controlled trial of warfarin targeting an international normalized ratio of 2.0 to 3.0 in patients with IPF. Subjects were randomized in a 1:1 ratio to warfarin or matching placebo for a planned treatment period of 48 weeks. International normalized ratios were monitored using encrypted home point-of-care devices that allowed blinding of study therapy. The primary outcome measure was the composite outcome of time to death, hospitalization (nonbleeding, nonelective), or a 10% or greater absolute decline in FVC. Due to a low probability of benefit and an increase in mortality observed in the subjects randomized to warfarin (14 warfarin versus 3 placebo deaths; P = 0.005) an independent Data and Safety Monitoring Board recommended stopping the study after 145 of the planned 256 subjects were enrolled (72 warfarin, 73 placebo). The mean follow-up was 28 weeks. ...Continue Reading

References

Jan 30, 1992·Statistics in Medicine·E Lakatos, K K Lan
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Jan 4, 2003·The Journal of Clinical Investigation·Shaun R Coughlin, Eric Camerer
Sep 16, 2005·Chest·Hiroshi KuboHidetada Sasaki
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Richard B HubbardAndrew W Fogarty
Oct 29, 2009·Respiratory Research·Jürgen BehrUNKNOWN IFIGENIA study group
Feb 20, 2010·American Journal of Respiratory and Critical Care Medicine·Birgitte F SodeBørge G Nordestgaard
Apr 29, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Boris FreidlinRobert Gray
Dec 15, 2010·Circulation·Michael D EzekowitzUNKNOWN RE-LY Steering Committee and Investigators
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jul 9, 2011·The European Respiratory Journal·D B SprungerJ J Swigris

❮ Previous
Next ❯

Citations

Aug 21, 2013·Current Allergy and Asthma Reports·Richard H Gomer
Sep 8, 2012·Current Opinion in Rheumatology·Lynne A MurrayErica L Herzog
Aug 6, 2013·Current Opinion in Pulmonary Medicine·Christopher King, Steven D Nathan
Oct 3, 2012·American Journal of Respiratory and Critical Care Medicine·Elisabeth Bendstrup, Ole Hilberg
Jan 17, 2013·American Journal of Respiratory and Critical Care Medicine·Argyris TzouvelekisDemosthenes Bouros
Feb 27, 2013·American Journal of Respiratory and Critical Care Medicine·Imre NothUNKNOWN IPFnet
Jul 4, 2012·American Journal of Respiratory and Critical Care Medicine·Joachim Müller-Quernheim, Athol Wells
Jul 17, 2012·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisPaul W Noble
May 3, 2013·American Journal of Respiratory and Critical Care Medicine·Hiroshi KuboArata Azuma
May 3, 2013·American Journal of Respiratory and Critical Care Medicine·Imre NothUNKNOWN IPFnet
May 3, 2013·American Journal of Respiratory and Critical Care Medicine·Moisés Selman, Annie Pardo
May 3, 2013·The Journal of Clinical Investigation·Detlef Schuppan, Yong Ook Kim
Aug 24, 2013·Respiratory Research·Dong Soon Kim
Nov 14, 2012·Multidisciplinary Respiratory Medicine·Paolo SpagnoloLuca Richeldi
Oct 12, 2012·Drug Design, Development and Therapy·Huzaifa I Adamali, Toby M Maher
Sep 18, 2013·Thorax·David B Coultas
Feb 4, 2014·American Journal of Respiratory and Critical Care Medicine·Imre Noth, Mitchell A Olman
Feb 4, 2014·American Journal of Respiratory and Critical Care Medicine·Galina S BogatkevichKristin B Highland
Nov 5, 2013·Thorax·Ricardo J JoséRachel C Chambers
Feb 26, 2014·Revue de pneumologie clinique·D Israël-BietC Delclaux
Dec 17, 2014·Translational Respiratory Medicine·Keith C Meyer
May 29, 2014·Mayo Clinic Proceedings·Jay H RyuAndrew H Limper
Aug 5, 2014·American Journal of Respiratory and Critical Care Medicine·Neil AhluwaliaAndrew M Tager
Nov 5, 2014·The Journal of Clinical Investigation·Shaik O RahamanMitchell A Olman
Jul 26, 2014·Drug Design, Development and Therapy·Steven D Nathan, Christopher S King
Dec 26, 2012·Expert Opinion on Pharmacotherapy·Harpreet K Lota, Athol U Wells
Dec 3, 2015·Expert Opinion on Emerging Drugs·Amen Sergew, Kevin K Brown
Jan 24, 2015·Annals of Medicine·Bashar S StaitiehSrihari Veeraraghavan
Jan 24, 2015·Annals of Medicine·Paolo SpagnoloCarlo Vancheri
Nov 14, 2015·Journal of Thrombosis and Haemostasis : JTH·Gustaaf G de RidderSalvatore V Pizzo
Jan 15, 2013·The American Journal of the Medical Sciences·J Shaun SmithCurt J Daniels
Feb 5, 2016·BMC Medicine·Bram RochwergHolger Schünemann
Feb 2, 2016·American Journal of Respiratory and Critical Care Medicine·Ahmed FahimSimon P Hart

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The New England Journal of Medicine
Idiopathic Pulmonary Fibrosis Clinical Research Network InvestigatorsFernando Martinez
American Journal of Respiratory and Critical Care Medicine
Joachim Müller-Quernheim, Athol U Wells
American Journal of Respiratory and Critical Care Medicine
Ganesh RaghuATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
© 2021 Meta ULC. All rights reserved