Abstract
Allopurinol improves endothelial function in chronic heart failure by reducing oxidative stress. We wished to explore if such an effect would attenuate autonomic dysfunction in CHF in line with many other effective therapies in CHF. We performed a prospective, randomized, double-blind cross-over study in 16 patients with NYHA Class II-IV chronic heart failure (mean age 67 +/- 10 years, 13 male, comparing allopurinol (2 months) at a daily dose of 300 mg (if creatinine < 150 micromol l-1) or 100 mg (if creatinine > 150 micromol l-1) with matched placebo. Mean heart rate and dysrhythmia counts were recorded from 24 h Holter tapes at monthly intervals for 6 months. We assessed autonomic function using standard time domain heart rate variability parameters (HRV): SDNN, SDANN, SDNN index, rMSSD and TI. Allopurinol had no significant effect on heart rate variability compared with placebo; the results are expressed as a difference in means +/- s.d. with 95% confidence interval (CI) between allopurinol and placebo: SDNN mean = 6.5 +/- 4.8 ms, P = 0.18 and 95% CI (-3.7, 17); TI mean = -2.1 +/- 1.4, P = 0.16 and 95% CI (-5.2, 0.8); SDANN mean = -2.8 +/- 7 ms, P = 0.68 and 95% CI (-18, 12); SDNNi mean = 2 +/- 6.6, P = 0.7 and 95% CI (-12, ...Continue Reading
References
Dec 15, 1992·The American Journal of Cardiology·S AdamopoulosA J Coats
Dec 21, 1991·Lancet·H DrexlerH Just
Jul 1, 1991·The Annals of Thoracic Surgery·M A Rashid, G William-Olsson
Feb 1, 1987·The American Journal of Cardiology·R E KleigerA J Moss
Oct 1, 1984·Circulation Research·A S ManningD J Hearse
Dec 1, 1994·British Heart Journal·Y S TuiningaK I Lie
May 1, 1994·American Heart Journal·P K SteinB M Conger
Jan 1, 1996·American Heart Journal·G PaninaP F Binkley
Jul 1, 1996·The American Journal of Cardiology·J JungC Ozbek
Jul 1, 1996·The American Journal of Cardiology·S JostP R Lichtlen
Aug 1, 1996·Circulation Research·H M Wright, K U Malik
May 1, 1997·European Heart Journal·M QuintanaM Ericson
Jul 1, 1997·Hypertension·C CardilloJ A Panza
Feb 3, 1998·European Heart Journal·K M Yee, A D Struthers
Apr 30, 1998·The Annals of Pharmacotherapy·D M BellL M Lopez
Sep 15, 1998·Lancet·M M Givertz, W S Colucci
Oct 14, 1998·Circulation·J NolanK A Fox
Dec 8, 1998·Circulation·M Malik
Dec 19, 1998·European Heart Journal·J A WijbengaM Malik
Jun 17, 1999·Clinical Science·S Chowdhary, J N Townend
Citations
Mar 2, 2006·Pharmacological Reviews·Pál PacherCsaba Szabó
Dec 24, 2009·Cardiovascular Psychiatry and Neurology·Peter HigginsMatthew Walters
Dec 6, 2016·Pharmacology & Therapeutics·Osita N OkaforDiana A Gorog
Oct 7, 2010·Heart Failure Reviews·Monali Y DesaiPaul J Hauptman
Nov 22, 2011·Cardiovascular Therapeutics·Peter HigginsMatthew R Walters
Feb 13, 2018·PloS One·Stanisław ZajączkowskiTomasz H Wierzba
Jun 5, 2002·Circulation·Wolfram DoehnerRainer Hambrecht