PMID: 8952856Jan 1, 1996Paper

A placebo-controlled study on urokinase therapy in systemic sclerosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
M L CiompiL Puccetti

Abstract

A 4-month randomized placebo controlled trial on urokinase therapy in 36 consecutive systemic sclerosis patients randomly treated with urokinase or placebo was conducted. While patients on placebo did not show any significant improvement, in those following urokinase therapy there was a noticeable improvement in skin sclerosis observed via hand-print and ultrasonography of the skin. Vascular involvement improved: this was demonstrated by capillaroscopy results, showing an improvement in pattern and signs of revascularization and the resolution of skin ulcers. Vascular damage is a typical occurrence in systemic sclerosis cases and various vasoactive drugs are used symptoms for some such as Raynaud's syndrome or skin ulcers. At the moment these drugs seem to constitute the most effective therapy, and have few side effects. We have found only one previous study utilizing urokinase therapy for acute digital ischemia in systemic sclerosis. Our study is the first in which urokinase therapy has been used for the treatment of systemic sclerosis in a large number of patients.

References

Nov 11, 1991·Annals of the Rheumatic Diseases·T A Medsger
Apr 1, 1989·Annals of Internal Medicine·P FenauxF Bauters
Feb 1, 1988·Postgraduate Medical Journal·A J BarnettG O Littlejohn
May 1, 1987·The British Journal of Dermatology·H Zachariae, E Zachariae
Sep 1, 1985·Clinical Rheumatology·P OrienteA Del Puente
Aug 1, 1993·The Journal of Cell Biology·M S PepperJ D Vassalli

❮ Previous
Next ❯

Citations

Apr 5, 2002·Arthritis and Rheumatism·Maria Kyriakidi, John P A Ioannidis
Apr 11, 2003·Current Treatment Options in Cardiovascular Medicine·Sergio GeneriniMarco Matucci Cerinic
Aug 29, 2013·International Journal of Rheumatic Diseases·Shereen S Ch'ngHelen I Keen
Nov 23, 2007·La Presse médicale·Camille FrancèsUNKNOWN Groupe français de recherche sur la sclérodermie
Jun 1, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Lorinda Chung
Sep 1, 2011·Expert Opinion on Medical Diagnostics·Martin Johannes KoehlerMartin Kaatz
Jun 2, 2009·Journal of Cutaneous Medicine and Surgery·Michele Ramien, Alain Brassard
Apr 29, 2008·Arthritis and Rheumatism·Renata VillelaUNKNOWN Canadian Scleroderma Research group
May 22, 2018·Arthritis Care & Research·Tânia SantiagoJ A P da Silva
Oct 15, 2010·International Journal of Immunopathology and Pharmacology·L PostiglioneP Ragno
Oct 11, 2017·Rheumatology·Felice GalluccioMarco Matucci-Cerinic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.