A placebo-controlled trial of constraint-induced movement therapy for upper extremity after stroke

Stroke; a Journal of Cerebral Circulation
Edward TaubAnjan Chatterjee

Abstract

Constraint-Induced Movement therapy (CI therapy) is a neurorehabilitation technique developed to improve use of the more affected upper extremity after stroke. A number of studies have reported positive effects for this intervention, but an experiment with a credible placebo control group has not yet been published. We conducted a placebo-controlled trial of CI therapy in patients with mild to moderate chronic (mean=4.5 years after stroke) motor deficit after stroke. The CI therapy group received intensive training (shaping) of the more affected upper extremity for 6 hours per day on 10 consecutive weekdays, restraint of the less affected extremity for a target of 90% of waking hours during the 2-week treatment period, and application of a number of other techniques designed to produce transfer to the life situation. The placebo group received a program of physical fitness, cognitive, and relaxation exercises for the same length of time and with the same amount of therapist interaction as the experimental group. After CI therapy, patients showed large (Wolf Motor Function Test) to very large improvements in the functional use of their more affected arm in their daily lives (Motor Activity Log; P<0.0001). The changes persisted o...Continue Reading

References

Mar 1, 1994·Journal of the Experimental Analysis of Behavior·E TaubN E Miller
Jun 2, 2001·Archives of Physical Medicine and Rehabilitation·D M MorrisE Taub
May 8, 2002·Nature Reviews. Neuroscience·Edward TaubThomas Elbert
Mar 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Bryan Kolb
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Edward TaubGitendra Uswatte
Oct 15, 2005·Stroke; a Journal of Cerebral Circulation·Gitendra UswatteKaren McCulloch
Jan 1, 1997·Topics in Stroke Rehabilitation·P W Duncan

❮ Previous
Next ❯

Citations

Feb 28, 2007·Current Neurology and Neuroscience Reports·Marjorie A GarveyPeter S Lum
May 13, 2009·Current Treatment Options in Cardiovascular Medicine·Richard L Harvey
Jun 28, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nneka L Ifejika-Jones, Anna M Barrett
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Alexander W DromerickJoseph Hidler
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Randolph J Nudo
Nov 26, 2009·Rehabilitation Psychology·Gitendra Uswatte, Laura Hobbs Qadri
Nov 13, 2013·Nature Reviews. Neurology·Steven L SmallAna Solodkin
Sep 14, 2007·Neuropsychological Rehabilitation·Tessa HartThomas A Novack
Sep 29, 2011·Neuropsychological Rehabilitation·Satoshi TanakaLeonardo G Cohen
Sep 5, 2009·Health & Social Work·Eric L Garland, Matthew Owen Howard
Jun 15, 2007·Journal of Neurologic Physical Therapy : JNPT·Stacy L FritzErin D Rivers
Oct 30, 2012·American Journal of Physical Medicine & Rehabilitation·Gitendra UswatteJoydip Barman
Mar 8, 2008·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
May 23, 2009·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
Sep 4, 2010·Stroke; a Journal of Cerebral Circulation·Steven L WolfLumy Sawaki
Nov 19, 2011·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
Jul 21, 2011·Journal of Child Neurology·Edward TaubCharles R Law
Sep 11, 2008·Neurorehabilitation and Neural Repair·Lumy SawakiGeorge F Wittenberg
Apr 29, 2010·Neurorehabilitation and Neural Repair·Rebecca L BirkenmeierCatherine E Lang
Feb 21, 2007·Journal of Neuroengineering and Rehabilitation·Maja J MatarićCarolee J Winstein
Jan 25, 2013·Experimental & Translational Stroke Medicine·Jessica M Livingston-Thomas, R Andrew Tasker
Sep 1, 2011·The Tohoku Journal of Experimental Medicine·Ina M TarkkaMervi Könönen
Feb 18, 2014·Experimental & Translational Stroke Medicine·Armin SchneiderWolf-Rüdiger Schäbitz
Apr 9, 2008·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·M ChevignardA Laurent-Vannier
Feb 11, 2014·American Journal of Physical Medicine & Rehabilitation·Tomokazu NomaKazumi Kawahira
Jul 5, 2007·Developmental Neurorehabilitation·Edward TaubCharles R Law
Jan 29, 2016·Behavioural Brain Research·Abigail L KerrAnjelica Rodriguez
Mar 8, 2007·Expert Review of Neurotherapeutics·Paolo ProficeVincenzo Di Lazzaro
Feb 5, 2010·Disability and Rehabilitation·Ann M Hammer, Birgitta Lindmark
Aug 12, 2015·Archives of Physical Medicine and Rehabilitation·Ya-Yun LeeChih-Kuang Chen
Feb 9, 2013·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Kelly P Westlake, Nancy N Byl
Apr 3, 2012·Archives of Physical Medicine and Rehabilitation·Marian E MichielsenJohannes B Bussmann
Nov 15, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shinji KagawaKazuhisa Domen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.