A placenta for life.

Reproductive Biomedicine Online
Rosalind John, M Hemberger

Abstract

The chorioallantoic placenta is the defining organ of eutherians that has enabled prolonged intrauterine gestation. As such, normal placental development and function are essential for mammalian reproductive success. Reflecting the key role of this organ in providing nutrients to the embryo, the characteristic cell type that forms substantial parts of the placenta is called 'trophoblast' (from Greek trephein 'to feed' and blastos 'germinator'). However, in addition to regulating nutrient supply, the placenta also exerts a number of other pivotal functions that highlight the importance of normal trophoblast differentiation for a successful pregnancy. In this guest symposium, 'Trophoblast Development', several contributors summarize insights gained from recent studies in the mouse that have advanced our understanding of trophoblast biology. This includes how the earliest trophoblast cells are set aside to expand in a stem- or progenitor-cell compartment under tight genetic and epigenetic control and how subsequent differentiation into the various placental cell types is controlled to ensure normal placentation. The relevance of these contributions range from early developmental cell fate decisions, stem cell biology and placental...Continue Reading

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Citations

Mar 1, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·S J TunsterR M John
Oct 9, 2014·Seminars in Immunopathology·Yiska WeisblumDana G Wolf
Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Julie Prudhomme, Céline Morey
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Apr 23, 2021·Cellular and Molecular Life Sciences : CMLS·Katrien De ClercqJoris Vriens
Jul 25, 2021·International Journal of Molecular Sciences·Isabel Garcia-MartinRosalind M John

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